Table 3

Predictors of diuretic therapy at first visit and follow-up study visits

CovariatesFirst study visitFollow-up study visits
βR2p ValueβR2p Value
Volume status included US0.57637.5<0.0010.57539.1<0.001
IVC category0.29020.7<0.0010.1396.2<0.001
IVC dimension0.26311.50.010.30218.6<0.001
Pleural effusion0.1099.00.020.88513.0<0.01
Volume status without US0.2847.50.030.34914.0<0.01
NYHA class0.1872.60.210.1683.90.14
  • β coefficients, coefficient of determination (R2) and level of significance assessed in univariate model with ‘Diuretic therapy’ as reduced (−1), unchanged (0) or increased (+1) as dependent variable and the listed covariates. By first study visit (n=62) oedema, NYHA class, weight, creatinine, and NT-proBNP were included as absolute values as described in the Methods section. By follow-up study visits the latter three covariates were included as relative change since last contact, and oedema and NYHA class were included as absolute changes, respectively. Pleural effusion was included as sum of semi-quantitative classification at first contact and as the average change of left and right pleural cavity graded as: −1, reduced measure >1 cm; +1, increased measure >1 cm; or 0 when change was <1 cm.

  • IVC, inferior vena cava; NT-proBNP, N-terminal pro-brain natriuretic peptide; NYHA, New York Heart Association; US, ultrasound assessment of the pleural cavities and IVC.