Table 2

Cox model estimating 15-year mortality for patients with and without a FH of CAD

	HR	95% CIs		Wald χ²	p Value
	HR	Lower	Upper	Wald χ²	p Value
(A) FH of CAD (n=6672)
CAC subsets				116	<0.0001
1–10	1.62	1.17	2.24	8	0.004
11–99	2.03	1.60	2.56	35	<0.0001
100–399	2.68	2.11	3.41	65	<0.0001
≥400	3.54	2.76	4.53	100	<0.0001
Age (in deciles)	1.35	1.24	1.46	54	<0.001
Male sex	0.95	0.80	1.12	<1	0.52
Current smoker	1.88	1.59	2.22	55	<0.001
Diabetes	2.32	1.89	2.84	64	<0.001
Hypertension	1.75	1.47	2.08	41	<0.001
Dyslipidaemia	0.66	0.56	0.78	24	<0.001
Model χ²=558, p<0.0001
(B) No FH of CAD (n=3043)
CAC subsets				148	<0.0001
1–10	1.55	0.97	2.48	8	0.067
11–-99	2.43	1.75	3.37	28	<0.0001
100–399	3.74	2.70	5.18	63	<0.0001
≥400	6.33	4.64	8.64	118	<0.0001
Age (in deciles)	1.52	1.37	1.67	67	<0.001
Male sex	1.12	0.90	1.40	1	0.298
Current smoker	1.49	1.21	1.84	14	<0.001
Diabetes	1.65	1.25	2.18	13	<0.001
Hypertension	1.27	1.02	1.57	5	0.033
Dyslipidaemia	0.77	0.62	0.95	6	0.016
Model χ²=429, p<0.0001

Bootstrap analysis with 1000 replicate samples noted minimal bias in the above models. This analysis can be found online as a suplementary file.
CAC, coronary artery calcium; CAD, coronary artery disease; FH, family history.