Table 1

Summary of studies identifying valve disease in patients previously treated with mediastinal radiotherapy

Study	Number of patients	Cancer type	Median age at exposure to radiotherapy	Median radiation dose (Gy)	Median follow-up (years)	Prevalence of VHD (%)	Definition of VHD	Prevalence of VHD in controls	Method VHD diagnosis
Gustavsson et al9	25	HL	24	40*	15	8 40	Moderate regurgitation Valve thickening	N/A	Echocardiography (pulse Doppler only)
Kreuser et al10	49	HL	35	Maximum 30	5.4	2 43	Moderate valve regurgitation Valve thickening	N/A	Echocardiography (pulse Doppler only)
Lund et al11	116	HL	N/A	41*	9*	31	>Grade 1 regurgitation	0% (healthy)	Echocardiography
Glanzmann et al12	144	HL	33.8*	Variable	13.7*	2.8	Moderate valve regurgitation or stenosis	N/A	Echocardiography
Heidenreich et al14	294	HL	N/A	43*	15*	29	≥Mild AR or ≥moderate MR or TR or any degree of stenosis	3% (age/sex matched)	Echocardiography
Hull et al13	415	HL	25	33	11.2	6	≥Moderate stenosis or regurgitation	N/A	Clinical records
Adams et al15	48	HL	16.5	40	14.3	42.6	≥Mild regurgitation or any stenosis	N/A	Echocardiography
Hooning et al17	4414	BC	49	N/A	17.7	4.2	ICD 9 code 424	N/A	Clinical records
Aleman et al16	1474	HL	25.7	N/A	18.7	10.9	N/A	N/A	Clinical records
Wethal et al18	51	HL	26	40	22	37	≥Moderate regurgitation	N/A	Echocardiography
Schellong et al19	1132	HL	12.8	25	15.1	2.9	≥Mild regurgitation or stenosis	N/A	Clinical records
McGale et al20	17 912	BC	N/A	N/A	N/A	0.5—left breast cancer	ICD 8, 9, 10 codes for valve disease	0.35%—right breast cancer	Clinical records
Galper et al21	1279	HL	25	40	14.7	6.1	≥Moderate stenosis or regurgitation	N/A	Clinical records
Bouillon et al22	3038	BC	N/A	N/A	28	0.4	Died from valve disease based on ICD 10 codes	N/A	Clinical records
Cutter et al23	1852	HL	N/A	37*	18.8	4.8	≥Moderate stenosis or regurgitation	N/A	Clinical records
van Nimwegen et al24	2524	HL	27.3	37	20.3	17	≥Moderate stenosis or regurgitation	N/A	Clinical records

*Mean.
AR, aortic regurgitation; BC, breast cancer; HL, Hodgkin's lymphoma; ICD, International Classification of Diseases; MR, mitral regurgitation; N/A, not available; TR, tricuspid regurgitation; VHD, valvular heart disease.