Association of long-term clinical course of childbearing-aged patients with ARVD/C with pregnancy history
| All (n=143) | Pregnancy with ARVD/C* (n=26) | No pregnancies while diagnosed (n=117) | p Value | |
|---|---|---|---|---|
| Demographic characteristics | ||||
| Proband (%) | 83 (58) | 13 (50) | 70 (60) | 0.36 |
| Mutation carrier (%) | 95 (67) | 16 (64) | 79 (68) | 0.69 |
| European ancestry | 138 (96) | 26 (100) | 112 (96) | 0.59 |
| Clinical characteristics at diagnosis | ||||
| Age (median, IQR) | 30 (21–39) | 28 (25–32) | 31 (21–41) | 0.14 |
| Sustained VT/VF (% VA) | 50 (35) | 6 (23) | 44 (38) | 0.16 |
| Heart failure ≥ Class C (%) | 2 (1.7) | 0 (0) | 2 (1.4) | 1.0 |
| Major RV structural abnormalities by Task Force Criteria (n=132) | 54/132 (41) | 8/25 (32) | 46/107 (43) | 0.31 |
| Cardiac outcomes at last follow-up | ||||
| Sustained VT/ICD shock (% VA) | 73 (51) | 12 (46) | 61 (52) | 0.58 |
| Heart failure ≥ Class C (%) | 16 (11) | 2 (8) | 14 (12) | 0.73 |
| Major RV structural abnormalities (by TFC) | 68 (48) | 10 (39) | 58 (50) | 0.31 |
| Transplant | 3 (2.1) | 0 (0) | 3 (2.6) | 1.0 |
| Death | 4 (3) | 1 (4) | 3 (3) | 0.56 |
| Follow-up duration (mean years from diagnosis) | 6.5±5.6 | 8.2±5.3 | 6.1±5.6 | 0.08 |
*Pregnancy proceeding beyond the first trimester. ARVD/C, arrhythmogenic right ventricular dysplasia/cardiomyopathy; ICD, implantable cardioverter defibrillator; RV, right ventricular; TFC, 2010 ARVD/C Task Force Criteria16; VA, sustained ventricular arrhythmia or appropriate ICD therapy for a ventricular arrhythmia; VF, ventricular fibrillation; VT, ventricular tachycardia.