TableĀ 3

Effects of anti-inflammatory therapy on CV events

Anti-inflammatory agentCV risk factorsCV events
csDMARDsDecrease in CRP, improvement in insulin resistance, lipid profile and physical activityDecrease
tsDMARDsDecreased CRP, increases lipidsDecrease
bDMARDsDecreased CRP, improvement in insulin resistance and lipid profile (except tocilizumab increases lipid levels)Decrease
NSAIDsIncreased blood pressure, possible increase in thrombo-embolic complications due to competitive COX-1 inhibition?Increase
GlucocorticosteroidsDecreased CRP, increased insulin resistance, increased blood pressure, weight gain, changes in body compositionIncrease, dose and duration dependent
  • bDMARDs, biological disease-modifying antirheumatic drugs; COX, cyclooxygenase; CRP, C reactive protein; csDMARDs, conventional synthetic disease-modifying antirheumatic drugs; CV, cardiovascular; tsDMARDs, targeted synthetic disease-modifying antirheumatic drugs.