Abstact 142 Table 1

Comparison of baseline quantitative CMR phenotypes in patients with and without truncating variants in TTN (TTNtv)

PhenotypeMean (sd) TTNtv+ (n = 62)Mean (sd) TTNtv- (n = 599)P value
LVEF (%)38.3 (13.9)39.3 (12.5)0.62
LVSVi (mls)43.2 (11.9)47.7 (14.8)0.03*
LVESVi (mls)78.8 (38.2)82.0 (39.1)0.32
LVEDVi (mls)122.9 (37.2)129.6 (42.1)0.17
LVMi (g)82.8 (21.4)93.3 (30.4)0.002*
Max LV wall thickness (mm)9.1(1.9)10.1 (2.2)<0.001*
Mean LV septal wall thickness (mm)7.3 (1.6)8.0 (1.9)0.003*
Mean LV lateral wall thickness (mm)5.0 (1.2)5.7(1.6)<0.001*
RVEF (%)36.1 (14.5)37.6 (13.9)0.47
RVSVi (mls)40.6 (13.7)44.4 (14.8)0.10
RVESVi (mls)42.6 (17.7)44.0 (22.8)0.94
RVEDVi (mls)83.2 (19.3)88.4 (28.9)0.44
  • * indicates significance at p < 0.05. LVEF/RVEF = Left/right ventricular ejection fraction. L/RVEDVi = indexed left/right ventricular end diastolic volume. L/RVESVi = indexed left/right ventricular end systolic volume. L/RVSVi = indexed left/right ventricular stroke volume. LVMi = indexed LV mass