Baseline characteristics of the study cohort
| Characteristic | All (n=46) | ODD+ (n=16) | ODD− (n=30) | p Value |
|---|---|---|---|---|
| Female | 22 (48%) | 9 (56%) | 13 (43%) | 0.538 |
| Age (years) | 14.1 (IQR 9.1 to 21.3) | 17.8 (IQR 10.2 to 26) | 13.7 (IQR 7.8 to 18.6) | 0.205 |
| Weight (kg) | 48.2±22.4 | 55.2±22.6 | 44.5±21.8 | 0.127 |
| Duration of Fontan circulation (years) | 10.8 (IQR 5.1 to 17.8) | 15.7 (IQR 6.4 to 23.2) | 10.5 (IQR 4.0 to 16.4) | 0.145 |
| RV morphology | 17 (37%) | 4 (25%) | 13 (43%) | 0.338 |
| ACE inhibitor therapy | 34 (74%) | 10 (63%) | 24 (80%) | 0.292 |
| Diuretic therapy | 6 (13%) | 2 (13%) | 4 (13%) | 0.936 |
| Fenestration present | 21 (46%) | 6 (38%) | 15 (50%) | 0.538 |
| Fontan type | 0.561 | |||
| Extracardiac conduit | 22 (48%) | 6 (38%) | 16 (53%) | – |
| Lateral tunnel | 21 (46%) | 9 (56%) | 12 (40%) | – |
| Atriopulmonary connection | 3 (7%) | 1 (6%) | 2 (7%) | – |
| Primary diagnoses | 0.742 | |||
| Tricuspid atresia | 11 (25%) | 5 (31%) | 6 (20%) | – |
| Pulmonary atresia | 8 (17%) | 3 (19%) | 5 (17%) | – |
| HLHS | 8 (17%) | 2 (13%) | 6 (20%) | – |
| DILV | 7 (15%) | 3 (19%) | 4 (13%) | – |
| Ebstein's anomaly | 3 (7%) | 3 (7%) | 3 (10%) | – |
| Other | 9 (20%) | 4 (25%) | 5 (17%) | – |
| Laboratory data | ||||
| Haemoglobin (g/dL) | 13.7±2.1 | 14.3±2.0 | 13.7±2.1 | 0.33 |
| Serum creatinine (mg/dL) | 0.72±0.25 | 0.79±0.26 | 0.62±0.2 | 0.2 |
Values are n (%), mean±SD or median (IQR). p Values reflect comparison between ODD+ and ODD− groups.
DILV, double inlet left ventricle; HLHS, hypoplastic left heart syndrome; ODD, occult diastolic dysfunction; RV, right ventricle.