Factors associated with excess mortality for cases of UPLMS PCI by CSA, NSTEACS, STEMI−CS and STEMI+CS
| CSA (n=3799) | NSTEACS (n=5114) | STEMI−CS (n=1020) | STEMI+CS (n=749) | |
|---|---|---|---|---|
| Variable added to baseline | EMRR | EMRR | EMRR | EMRR |
| Baseline model+previous MI | 2.73 (1.77 to 4.21)* | 1.55 (1.34 to 1.80)* | 1.18 (1.79 to 1.77) | 0.97 (0.75 to 1.26) |
| Baseline model+diabetes | 2.56 (1.64 to 3.97)* | 1.66 (1.43 to 1.95)* | 1.69 (1.15 to 2.48)* | 1.34 (1.04 to 1.72)* |
| Baseline model+LVSD | ||||
| Good | 1.00 | 1.00 | † | † |
| Moderate LVSD | 2.43 (1.38 to 4.29)* | 2.34 (1.86 to 2.93)* | ||
| Severe LVSD | 3.90 (2.23 to 6.82)* | 3.65 (2.96 to 4.51)* | ||
| Baseline model+renal failure | 6.73 (4.06 to 11.15)* | 3.25 (2.75 to 3.84)* | 2.27 (1.20 to 4.27)* | 1.77 (1.13 to 2.75)* |
| Baseline model+preprocedure flow in IRA | ||||
| TIMI 3 (normal flow) (reference) | 1.00 | 1.00 | 1.00 | 1.00 |
| TIMI 0 (no flow) | ‡ | ‡ | 1.66 (0.96 to 2.87) | 2.78 (1.87 to 4.13)* |
| TIMI 1 (partial flow) | 1.99 (1.01 to 3.92)* | 2.32 (1.49 to 3.63)* | ||
| TIMI 2 (slow flow) | 1.40 (0.74 to 2.65) | 2.00 (1.26 to 3.17)* | ||
| Baseline model+vessels attempted | ||||
| One vessel | 1.00 | 1.00 | 1.00 | 1.00 |
| Multivessel PCI | 1.52 (0.85 to 2.71) | 0.90 (0.77 to 1.05) | 0.88 (0.62 to 1.24) | 0.74 (0.61 to 0.90)* |
| Baseline model+number of stents | ||||
| No stent | 1.00 | 1.00 | 1.00 | 1.00 |
| One stent | 1.25 (0.41 to 3.77) | 0.93 (0.67 to 1.29) | 0.31 (0.18 to 0.54)* | 0.45 (0.32 to 0.62)* |
| More than one stent | 2.20 (0.79 to 6.12) | 0.92 (0.68 to 1.26) | 0.32 (0.20 to 0.53)* | 0.42 (0.31 to 0.57)* |
| Other interventions | ||||
| Baseline model+preprocedural ventilation | ‡ | 6.25 (5.05 to 7.75)* | 6.92 (4.25 to 11.26)* | 2.03 (1.66 to 2.50)* |
| Baseline model+LMS stenosis preprocedure | 1.82 (1.02 to 3.23)* | 2.09 (1.64 to 2.66)* | 1.60 (1.01 to 2.41)* | 1.03 (0.73 to 1.43) |
| Baseline model+GPIIb/IIa inhibitors | 0.87 (0.51 to 1.49) | 0.99 (0.84 to 1.17) | 0.42 (0.29 to 0.59)* | 0.83 (0.68 to 1.02) |
| Baseline model+IVUS | 0.46 (0.28 to 0.76)* | 0.47 (0.39 to 0.57)* | 0.43 (0.24 to 0.74)* | 0.28 (0.17 to 0.46)* |
| Baseline model+ FFR | 0.30 (0.08 to 1.19) | 0.44 (0.25 to 0.75)* | ‡ | ‡ |
Results are pooled estimates over 20 imputations.
*Significance at 5% level.
†Level of missingness detected >50% hence variable not imputed and excluded from model.
‡Small number of cases.
CAD, cardiovascular disease; CSA, chronic stable angina; FFR, fractional flow reserve; IRA, infarct-related artery; IVUS, intravascular ultrasound; LMS, left main stem; LVSD, left ventricular systolic function; MI, acute myocardial infarction; NSTEACS, non-ST-segment elevation acute coronary syndrome; PCI, percutaneous coronary; STEMI, ST-segment elevation myocardial infarction; TIMI, thrombolysis in myocardial infarction; UPLMS, unprotected left main stem.