Table 2

Factors associated with excess mortality for cases of UPLMS PCI by CSA, NSTEACS, STEMI−CS and STEMI+CS

CSA
(n=3799)
NSTEACS
(n=5114)
STEMI−CS
(n=1020)
STEMI+CS
(n=749)
Variable added to baselineEMRREMRREMRREMRR
Baseline model+previous MI2.73 (1.77 to 4.21)*1.55 (1.34 to 1.80)*1.18 (1.79 to 1.77)0.97 (0.75 to 1.26)
Baseline model+diabetes2.56 (1.64 to 3.97)*1.66 (1.43 to 1.95)*1.69 (1.15 to 2.48)*1.34 (1.04 to 1.72)*
Baseline model+LVSD
 Good1.001.00
 Moderate LVSD2.43 (1.38 to 4.29)*2.34 (1.86 to 2.93)*
 Severe LVSD3.90 (2.23 to 6.82)*3.65 (2.96 to 4.51)*
 Baseline model+renal failure6.73 (4.06 to 11.15)*3.25 (2.75 to 3.84)*2.27 (1.20 to 4.27)*1.77 (1.13 to 2.75)*
Baseline model+preprocedure flow in IRA
 TIMI 3 (normal flow) (reference)1.001.001.001.00
 TIMI 0 (no flow)1.66 (0.96 to 2.87)2.78 (1.87 to 4.13)*
 TIMI 1 (partial flow)1.99 (1.01 to 3.92)*2.32 (1.49 to 3.63)*
 TIMI 2 (slow flow)1.40 (0.74 to 2.65)2.00 (1.26 to 3.17)*
Baseline model+vessels attempted
 One vessel1.001.001.001.00
 Multivessel PCI1.52 (0.85 to 2.71)0.90 (0.77 to 1.05)0.88 (0.62 to 1.24)0.74 (0.61 to 0.90)*
Baseline model+number of stents
 No stent1.001.001.001.00
 One stent1.25 (0.41 to 3.77)0.93 (0.67 to 1.29)0.31 (0.18 to 0.54)*0.45 (0.32 to 0.62)*
 More than one stent2.20 (0.79 to 6.12)0.92 (0.68 to 1.26)0.32 (0.20 to 0.53)*0.42 (0.31 to 0.57)*
Other interventions
 Baseline model+preprocedural ventilation6.25 (5.05 to 7.75)*6.92 (4.25 to 11.26)*2.03 (1.66 to 2.50)*
 Baseline model+LMS stenosis preprocedure1.82 (1.02 to 3.23)*2.09 (1.64 to 2.66)*1.60 (1.01 to 2.41)*1.03 (0.73 to 1.43)
 Baseline model+GPIIb/IIa inhibitors0.87 (0.51 to 1.49)0.99 (0.84 to 1.17)0.42 (0.29 to 0.59)*0.83 (0.68 to 1.02)
 Baseline model+IVUS0.46 (0.28 to 0.76)*0.47 (0.39 to 0.57)*0.43 (0.24 to 0.74)*0.28 (0.17 to 0.46)*
 Baseline model+ FFR0.30 (0.08 to 1.19)0.44 (0.25 to 0.75)*
  • Results are pooled estimates over 20 imputations.

  • *Significance at 5% level.

  • †Level of missingness detected >50% hence variable not imputed and excluded from model.

  • ‡Small number of cases.

  • CAD, cardiovascular disease; CSA, chronic stable angina; FFR, fractional flow reserve; IRA, infarct-related artery; IVUS, intravascular ultrasound; LMS, left main stem; LVSD, left ventricular systolic function; MI, acute myocardial infarction; NSTEACS, non-ST-segment elevation acute coronary syndrome; PCI, percutaneous coronary; STEMI, ST-segment elevation myocardial infarction; TIMI, thrombolysis in myocardial infarction; UPLMS, unprotected left main stem.