Regression between LAVI at 60–64 years and SBP and antihypertensive treatment at four time points with further adjustment for covariables (n=1417 for all models—with valid outcome and SBP at age 60–64 years)
| Model 1 | Model 2 | Model 3 | Model 4 | Model 5 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Independent variable | β (95% CI) | p Value | β (95% CI) | p Value | β (95% CI) | p Value | β (95% CI) | p Value | β (95% CI) | p Value | |
| Age 36 (n=1417) | SBP | 0.042 (0.013 to 0.072) | 0.005 | 0.041 (0.012 to 0.071) | 0.006 | 0.035 (0.004 to 0.065) | 0.025 | 0.38 (0.008 to 0.068) | 0.014 | 0.024 (−0.005 to 0.053) | 0.103 |
| Age 43 (n=1417) | SBP | 0.042 (0.013 to 0.070) | 0.004 | 0.040 (0.011 to 0.069) | 0.006 | 0.021 (0.001 to 0.061) | 0.042 | 0.035 (0.005 to 0.064) | 0.021 | 0.026 (−0.003 to 0.055) | 0.079 |
| Age 53 (n=1417) | SBP | 0.056 (0.036 to 0.075) | <0.001 | 0.047 (0.027 to 0.068) | <0.001 | 0.043 (0.021 to 0.065) | <0.001 | 0.038 (0.016 to 0.060) | 0.001 | 0.023 (0.023 to 0.045) | 0.035 |
| Age 60–64 (n=1417) | SBP | 0.030 (0.009 to 0.051) | 0.004 | 0.028 (0.008 to 0.050) | 0.007 | NR | NR | 0.020 (−0.013 to 0.041) | 0.066 | −0.001 (−0.023 to 0.022) | 0.944 |
| Age 36 | HTT | NR | NR | 2.560 (−1.650 to 6.771) | 0.232 | 2.769 (−1.433 to 6.971) | 0.195 | 1.931 (−2.262 to 6.124) | 0.365 | 2.022 (−1.935 to 5.979) | 0.315 |
| Age 43 | HTT | NR | NR | 2.179 (−0.393 to 4.751) | 0.097 | 2.205 (−0.352 to 4.762) | 0.091 | 1.388 (−1.204 to 3.981) | 0.293 | 0.657 (−1.826 to 3.141) | 0.603 |
| Age 53 | HTT | NR | NR | 2.304 (1.139 to 3.469) | <0.001 | 2.326 (1.161 to 3.491) | <0.001 | 1.979 (0.799 to 3.159) | 0.001 | 1.418 (0.260 to 2.576) | 0.016 |
| Age 60–64 | HTT | NR | NR | 1.290 (0.667 to 2.512) | 0.001 | – | NR | 1.084 (0.134 to 2.033) | 0.025 | 0.6453 (−0.466 to 1.371) | 0.334 |
The variable β is regression coefficient for LAVI versus SBP (mm Hg) or antihypertensive treatment (HTT). Model 1: adjusted for age sex and CRF attended. Model 2: model 1+HTT at given age (for SBP) or model 1+SBP at given age (for HTT). Model 3: model 2+SBP at 60–64 years. Model 4: model 3+diabetes mellitus+body mass index+smoking status+physical activity status. Model 5: model 4+left ventricular mass indexed to body surface area. Numbers of individuals receiving HTT were 51 (2%), 107 (3%), 438 (15%) and 640 (27%) at age 36, 43, 53 and 60–64 years, respectively.
CRF, clinical research facility; LAVI, left atrial volume indexed to body surface area; NR, not relevant; SBP, systolic blood pressure.