Table 1

Baseline characteristics of patients in cohorts 1 to 4

VariableCohort 1
2010–2011
(n=5500)
Cohort 2
2011–2013
(n=11 662)
Cohort 3
2013–2014
(n=11 462)
Cohort 4
2014–2015
(n=11 046)
Female, n/N (%)2402/5500 (43.7)5116/11 662 (43.9)5191/11 462 (45.3)4870/11 046 (44.1)
Age at diagnosis, years, mean (SD)69.8 (11.5)69.8 (11.4)69.6 (11.4)a69.6 (11.7)
Ethnicity, n/N (%)
 Caucasian/Hispanic/Latino3691/5500 (67.1)8647/11 662 (74.1)7896/11 462 (68.9)7050/11 046 (63.8)
 Asian1589/5500 (28.8)2392/11 662 (20.5)3175/11 462 (27.7)3574/11 046 (32.4)
 Other68/5500 (1.2)244/11 662 (2.1)147/11 462 (1.3)239/11 046 (2.2)
 Unwilling to declare152/5500 (2.8)379/11 662 (3.2)244/11 462 (2.1)183/11 046 (1.7)
Medical history, n/N (%)
 CHF1026/5498 (18.7)2506/11 662 (21.5)2206/11 462 (19.2)2128/11 046 (19.3)
 CAD1059/5498 (19.3)2357/11 662 (20.2)2495/11 462 (21.8)2428/11 046 (22.0)
 ACS553/5498 (10.1)1061/11 659 (9.1)1258/11 257 (11.2)1281/10 884 (11.8)
 Vascular disease847/5498 (15.4)1653/11 662 (14.2)1828/11 462 (15.9)1789/11 046 (16.2)
 Systemic embolism35/5498 (0.6)74/11 652 (0.6)85/11 383 (0.7)78/10 981 (0.7)
 Stroke/TIA727/5498 (13.2)1459/11 662 (12.5)1236/11 462 (10.8)1219/11 046 (11.0)
 Bleeding172/5498 (3.1)325/11 651 (2.8)283/11 400 (2.5)262/10 995 (2.4)
 History of hypertension4224/5498 (76.8)9172/11 662 (78.6)8761/11 419 (76.7)8224/11 004 (74.7)
 Diabetes mellitus1215/5498 (22.1)2535/11 662 (21.7)2457/11 462 (21.4)2443/11 046 (22.1)
 Moderate-to-severe CKD*495/5497 (9.0)1265/11 662 (10.8)1209/11 462 (10.5)1104/11 045 (10.0)
Risk scores
 CHA2DS2-VASc, median (Q1–Q3)3 (2–4)b3 (2–4)c3 (2–4)d3 (2–4)e
 CHA2DS2-VASc, 0–1, n/N (%)815/5406 (15.1)1531/11 293 (13.6)1666/11 252 (14.8)1700/10 830 (15.7)
 HAS-BLED, median (Q1–Q3)†1 (1–2)f1 (1–2)g1 (1–2)h1 (1–2)i
 HAS-BLED, 0–2, n/N (%)†3109/3561 (87.3)6321/7302 (86.6)7650/8584 (89.1)7824/8654 (90.4)
  • a1 patient missing; b94 patients missing; c369 patients missing; d210 patients missing; e216 patients missing; f1939 patients missing; g4360 patients missing; h2878 patients missing; i2392 patients missing.

  • ACS, acute coronary syndrome; CAD, coronary artery disease; CHA2DS2-VASc, cardiac failure, hypertension, age ≥75 (doubled), diabetes, stroke (doubled)-vascular disease, age 65–74 and sex category (female); CHF, congestive heart failure; CKD, chronic kidney disease; NKF KDOQI, National Kidney Foundation's Kidney Disease Outcomes Quality Initiative; TIA, transient ischaemic attack.

  • *Includes NKF KDOQI stages III–V.

  • †‘modified’ HAS-BLED, hypertension, abnormal renal/liver function (1 point each), stroke, bleeding history or predisposition, elderly (>65), drugs/alcohol concomitantly (1 point each).