Area under the receiver operating characteristic curve (AUROC) (95% CI) and detection rates for the combined data
| AUROC for combined studies | Detection rate for 5% false-positive | Detection rate for 10% false-positive | |
|---|---|---|---|
| Externally weighted gene score | 0.524 (0.508 to 0.541) | 6.8% (5.5 to 8.1) | 13.1% (11.3 to 14.8) |
| QRISK-2 | 0.635 (0.619 to 0.650) | 11.9% (10.3 to 13.6) | 21.2% (19.1 to 23.3) |
| QRISK-2+ Externally weighted gene score | 0.623 (0.608 to 0.639) p=0.06* | 12.0% (10.3 to 13.6) | 19.6% (17.5 to 21.6) |
*p Value derived from the comparison with QRISK-2 alone, estimated difference (95% CI)=−0.008 (−0.017 to 0.000).