Subgroup | Duration of mortality treatment effect | Lifetime mortality and constant HRQoL | |||
---|---|---|---|---|---|
Lifetime | 7.5 years | 5 years | Mean f/up | ||
Individuals without LBBB | |||||
NYHA I, QRS <120 ms* | ICD | ICD | ICD | ICD | ICD |
NYHA I, QRS ≥120 ms and <150 ms* | ICD | ICD | ICD | ICD | ICD |
NYHA I, QRS ≥150 ms* | CRT-D | CRT-D | CRT-D | CRT-D | CRT-D |
NYHA II, QRS <120 ms | ICD | ICD | ICD | ICD | ICD |
NYHA II, QRS ≥120 ms and <150 ms | ICD | ICD | ICD | ICD | ICD |
NYHA II, QRS ≥150 ms | CRT-D | CRT-D | CRT-D | CRT-D | CRT-D |
NYHA III, QRS <120 ms | ICD | ICD | ICD | MT | ICD |
NYHA III, QRS ≥120 ms and <150 ms | CRT-D | CRT-D | CRT-D | CRT-D | CRT-D |
NYHA III, QRS ≥150 ms | CRT-D | CRT-D | CRT-D | CRT-D | CRT-D |
NYHA IV, QRS <120 ms | MT | MT | MT | MT | MT |
NYHA IV, QRS ≥120 ms and <150 ms | CRT-P | CRT-P | CRT-P | CRT-P | CRT-P |
NYHA IV, QRS ≥150 ms | CRT-P | CRT-P | CRT-P | CRT-P | CRT-P |
Individuals with LBBB | |||||
NYHA I, QRS ≥120 ms and <150 ms* | CRT-D | CRT-D | CRT-D | CRT-D | CRT-D |
NYHA I, QRS ≥150 ms* | CRT-D | CRT-D | CRT-D | CRT-D | CRT-D |
NYHA II, QRS ≥120 ms and <150 ms | CRT-D | CRT-D | CRT-D | CRT-D | CRT-D |
NYHA II, QRS ≥150 ms | CRT-D | CRT-D | CRT-D | CRT-D | CRT-D |
NYHA III, QRS ≥120 ms and <150 ms | CRT-D | CRT-D | CRT-D | CRT-D | CRT-D |
NYHA III, QRS ≥150 ms | CRT-D | CRT-D | CRT-P | CRT-P | CRT-D |
NYHA IV, QRS ≥120 ms and <150 ms | CRT-P | CRT-P | CRT-P | CRT-P | CRT-P |
NYHA IV, QRS ≥150 ms | CRT-P | CRT-P | CRT-P | CRT-P | CRT-P |
Changes from base case highlighted in bold.
*Results in NYHA I and IV patients are based on relatively low patient numbers and may be subject to bias due to the nature of trial inclusion criteria for NYHA I patients. For further detail see main text.
CRT, cardiac resynchronisation therapy; CRT-D, combined CRT and ICD device; CRT-P, stand-alone CRT device; HRQoL, health-related quality of life; ICD, implantable cardioverter defibrillator; LBBB, left bundle branch block; MT, medical therapy; NYHA, New York Heart Association; QALY, quality-adjusted life-year.