Table 1

Base case results. Cost-effectiveness sequence relates to the order in which interventions appear on the cost-effectiveness frontier

	Cost-effectiveness sequence				Incremental cost-effective ratios
Patient group	1st	2nd	3rd	4th	1st	2nd	3rd	4th
Individuals without LBBB morphology
NYHA I, QRS duration <120 ms*	MT	ICD	N/A	N/A	Referent	£24 074	N/A	N/A
NYHA I, QRS duration ≥120 ms and <150 ms*	MT	CRT-D	ICD	N/A	Referent	Dominated	£16 253	N/A
NYHA I, QRS duration ≥150 ms*	MT	ICD	CRT-D	N/A	Referent	£21 102	£21 759	N/A
NYHA II, QRS duration <120 ms	MT	ICD	N/A	N/A	Referent	£24 465	N/A	N/A
NYHA II, QRS duration ≥120 ms and <150 ms	MT	CRT-D	ICD	N/A	Referent	Dominated	£16 813	N/A
NYHA II, QRS duration ≥150 ms	MT	ICD	CRT-D	N/A	Referent	£20 602	£23 738	N/A
NYHA III, QRS duration <120 ms	MT	ICD	N/A	N/A	Referent	£27 826	N/A	N/A
NYHA III, QRS duration≥120 ms and <150 ms	MT	CRT-P	ICD	CRT-D	Referent	£20 178	Ext Dominated	£23 349
NYHA III, QRS duration ≥150 ms	MT	ICD	CRT-P	CRT-D	Referent	Dominated	£13 930	£25 200
NYHA IV, QRS duration <120 ms	MT	N/A	N/A	N/A	Referent	N/A	N/A	N/A
NYHA IV, QRS duration ≥120 ms and <150 ms	MT	CRT-P	CRT-D	N/A	Referent	£22 578	£40 052	N/A
NYHA IV, QRS duration ≥150 ms	MT	CRT-P	CRT-D	N/A	Referent	£17 175	£35 811	N/A
Individuals with LBBB morphology
NYHA I, QRS duration ≥120 ms and <150 ms*	MT	ICD	CRT-D	N/A	Referent	£20 677	£21 672	N/A
NYHA I, QRS duration ≥150 ms*	MT	ICD	CRT-D	N/A	Referent	Ext Dominated	£17 470	N/A
NYHA II, QRS duration ≥120 ms and <150 ms	MT	ICD	CRT-D	N/A	Referent	Ext Dominated	£20 704	N/A
NYHA II, QRS duration ≥150 ms	MT	ICD	CRT-D	N/A	Referent	Ext Dominated	£17 664	N/A
NYHA III, QRS duration ≥120 ms and <150 ms	MT	ICD	CRT-P	CRT-D	Referent	Dominated	£14 215	£24 875
NYHA III, QRS duration ≥150 ms	MT	ICD	CRT-P	CRT-D	Referent	Dominated	£10 496	£28 646
NYHA IV, QRS duration ≥120 ms and <150 ms	MT	CRT-P	CRT-D	N/A	Referent	£18 664	£37 104	N/A
NYHA IV, QRS duration ≥150 ms	MT	CRT-P	CRT-D	N/A	Referent	£14 500	£40 449	N/A

‘N/A’ represents fewer than four interventions being considered. Options labelled as ‘Dominated’ or ‘Ext Dominated’ do not lie on the frontier.
*Results in NYHA I and IV patients are based on relatively low patient numbers and may be subject to bias due to the nature of trial inclusion criteria for NYHA I patients. For further detail see main text.
CRT, cardiac resynchronisation therapy; CRT-D, combined CRT and ICD device; CRT-P, stand-alone CRT device; ICD, implantable cardioverter defibrillator; LBBB, left bundle branch block; MT, medical therapy; N/A, not applicable; NYHA, New York Heart Association.