Baseline and follow-up CMR
| Culprit-artery-only PCI | Preventive PCI | p Value | |
|---|---|---|---|
| CMR at baseline, n=84* | n=42 | n=42 | |
| LV ejection fraction, %† | 47.9 (40.3, 47.9) | 48.5 (38.6, 55.8) | 0.96 |
| LV end-diastolic volume index, mL/m2† | 64.8 (57.1, 77.4) | 68.5 (54.7, 79.0) | 0.86 |
| LV end-systolic volume index, mL/m2† | 33.5 (27.3, 47.8) | 34.1 (25.5, 49.1) | 0.92 |
| Total infarct size (% LVM)*‡ | n=41 | n=41 | |
| Median (IQR) | 15.66 (6.18, 28.78) | 14.62 (4.81, 20.10) | 0.33 |
| Mean (SD) | (18.12 (13.85)) | (14.83 (11.75)) | – |
| Time from PPCI (days), mean (range) | 5 (0–32) | 4 (1–14) | 0.41 |
| Infarct on LGE, n (%) | 37 (90) | 39 (95) | 0.67 |
| Microvascular obstruction, n (%) | 10 (24) | 8 (20) | 0.60 |
| Microvascular obstruction, % LV mass† | 0.00 (0.00, 0.60) range (0.00:0.28) | 0.00 (0.00, 0.00) range (0.00:0.15) | 0.64 |
| Infarct in non-infarct-related artery territory, n (%) | 2 (5) | 4 (10) | 0.68 |
| Acute infarct in non-infarct-related artery territory, n (%) | 0 (0) | 2 (5) | 0.15 |
| Culprit-artery infarct size (% LVM) irrespective of acute or chronic§ | |||
| Median (IQR) | 15.66 (6.18, 28.78) | 13.25 (3.87, 17.85) | 0.16 |
| Mean (SD) | (17.91 (13.91)) | (13.55 (11.60)) | – |
| Non-culprit-artery infarct size (% LVM) | |||
| Mean±SD | 4.34±0.79 | 9.70±4.41 | 0.11 |
| Follow-up CMR | n=37 | n=35 | |
| Time to CMR (days), median (IQR) | 210 (195, 994) | 209 (186, 419) | 0.42 |
| Total infarct size (% LVM)‡ | |||
| Median (IQR) | 13.43 (3.30, 22.15) | 7.68 (2.10, 12.09) | 0.14 |
| Infarct on LGE, n (%) | 35 (95) | 32 (91) | 0.66 |
| Patients with >1 infarct, n (%) | 4 (11) | 5 (14) | 0.73 |
| Adverse remodelling, n (%) | 4 (10) | 7 (17) | 0.52 |
| LV ejection fraction, %† | 51.7 (42.9, 60.2) | 54.4 (49.3, 62.8) | 0.23 |
| LV end-diastolic volume index, mL/m2† | 69.3 (59.4, 79.9) | 66.1 (54.7, 73.7) | 0.48 |
| LV end-systolic volume index, mL/m2† | 31.8 (24.4, 43.0) | 30.7 (23.0, 36.3) | 0.20 |
*One of the patients randomised to culprit-artery-only PCI had an estimated glomerular filtration rate (eGFR) <30 mL/min/1.73 m2 and thus IV gadolinium contrast agent was not administered. One of the patients randomised to preventive PCI could not tolerate the CMR scan, scanning was terminated after acquisition of cine sequences. % LVM (% left ventricular mass).
†Mean (SD) or median (IQR).
‡Total infarct size includes both acute and chronic infarcts.
§Acute infarct size adjusted (age, anterior MI, TIMI pre-coronary intervention, time to reperfusion, diabetes mellitus (DM), Rentrop) gives a p value of 0.735 comparing culprit-artery-only PCI with preventive PCI.
CMR, cardiac magnetic resonance; LV, left ventricular; PCI, percutaneous coronary intervention; PPCI, primary percutaneous coronary intervention.