Univariable and multivariable regression analyses of the predictors of mean transvalvular gradient
| Univariable analysis | Multivariable analysis | |||
|---|---|---|---|---|
| Standardised β | p Value | Standardised β | p Value | |
| Whole cohort (n=200) | ||||
| Age | −0.10 | 0.15 | −0.21 | 0.02 |
| Men | 0.10 | 0.16 | −0.06 | 0.36 |
| Height | 0.07 | 0.36 | – | – |
| Weight | −0.05 | 0.48 | – | – |
| Body mass index | −0.09 | 0.23 | – | – |
| Body surface area | −0.009 | 0.90 | – | – |
| √AVCd | 0.44 | <0.0001 | 0.59 | <0.0001 |
| BAV | 0.22 | 0.002 | 0.18 | 0.04 |
| Hypertension | −0.01 | 0.88 | – | – |
| Dyslipidemia | −0.01 | 0.84 | – | – |
| Diabetes | −0.14 | 0.046 | −0.08 | 0.18 |
| History of smoking | −0.11 | 0.11 | – | – |
| Coronary artery disease | −0.07 | 0.33 | – | – |
| TAV (n=161) | ||||
| Age | 0.15 | 0.054 | −0.06 | 0.36 |
| Men | 0.19 | 0.02 | 0.01 | 0.82 |
| Height | 0.10 | 0.23 | – | – |
| Weight | −0.03 | 0.70 | – | – |
| Body mass index | −0.07 | 0.40 | – | – |
| Body surface area | 0.02 | 0.84 | – | – |
| √AVCd | 0.63 | <0.0001 | 0.65 | <0.0001 |
| Hypertension | 0.14 | 0.08 | 0.02 | 0.78 |
| Dyslipidemia | 0.11 | 0.15 | – | – |
| Diabetes | −0.11 | 0.17 | – | – |
| History of smoking | −0.04 | 0.61 | – | – |
| Coronary artery disease | 0.02 | 0.79 | – | – |
| BAV (n=39) | ||||
| Age | −0.13 | 0.43 | −0.49 | 0.02 |
| Men | 0.02 | 0.90 | −0.32 | 0.10 |
| Height | −0.07 | 0.66 | – | – |
| Weight | −0.02 | 0.92 | – | – |
| Body mass index | 0.01 | 0.94 | – | – |
| Body surface area | −0.03 | 0.87 | – | – |
| √AVCd | 0.24 | 0.14 | 0.67 | 0.005 |
| Hypertension | 0.005 | 0.98 | – | – |
| Dyslipidemia | 0.003 | 0.99 | – | – |
| Diabetes | −0.09 | 0.58 | – | – |
| History of smoking | −0.21 | 0.20 | – | – |
| Coronary artery disease | −0.11 | 0.52 | – | – |
| TAV<72 years old (n=77) | ||||
| Men | 0.13 | 0.25 | −0.04 | 0.67 |
| Height | 0.06 | 0.60 | – | – |
| Weight | 0.02 | 0.85 | – | – |
| Body mass index | 0.03 | 0.81 | – | – |
| Body surface area | 0.05 | 0.67 | – | – |
| √AVCd | 0.66 | <0.0001 | 0.63 | <0.0001 |
| Hypertension | 0.25 | 0.03 | 0.13 | 0.16 |
| Dyslipidemia | 0.18 | 0.12 | – | – |
| Diabetes | −0.22 | 0.06 | −0.21 | 0.02 |
| History of smoking | −0.08 | 0.52 | – | – |
| Coronary artery disease | 0.08 | 0.48 | – | – |
| TAV≥72 years old (n=84) | ||||
| Men | 0.25 | 0.02 | 0.08 | 0.37 |
| Height | 0.15 | 0.17 | – | – |
| Weight | −0.07 | 0.51 | – | – |
| Body mass index | −0.17 | 0.13 | – | – |
| Body surface area | 0.004 | 0.97 | – | – |
| √AVCd | 0.60 | <0.0001 | 0.58 | <0.0001 |
| Hypertension | 0.03 | 0.76 | – | – |
| Dyslipidemia | 0.04 | 0.70 | – | – |
| Diabetes | −0.005 | 0.96 | – | – |
| History of smoking | −0.009 | 0.94 | – | – |
| Coronary artery disease | −0.05 | 0.65 | – | – |
| BAV<51 years old (n=18) | ||||
| Men | −0.18 | 0.48 | −0.32 | 0.36 |
| Height | −0.28 | 0.27 | – | – |
| Weight | 0.05 | 0.84 | – | – |
| Body mass index | 0.24 | 0.33 | – | – |
| Body surface area | −0.03 | 0.90 | – | – |
| √AVCd | −0.005 | 0.99 | 0.21 | 0.55 |
| Hypertension | −0.05 | 0.83 | – | – |
| Dyslipidemia | −0.09 | 0.73 | – | – |
| Diabetes | – | – | – | – |
| History of smoking | −0.35 | 0.15 | – | – |
| Coronary artery disease | −0.14 | 0.59 | – | – |
| BAV≥51 years old (n=21) | ||||
| Men | 0.27 | 0.24 | −0.18 | 0.41 |
| Height | 0.17 | 0.46 | – | – |
| Weight | −0.11 | 0.64 | – | – |
| Body mass index | −0.28 | 0.22 | – | – |
| Body surface area | −0.02 | 0.93 | – | – |
| √AVCd | 0.67 | 0.001 | 0.77 | 0.002 |
| Hypertension | 0.08 | 0.74 | – | – |
| Dyslipidemia | 0.09 | 0.68 | – | – |
| Diabetes | −0.15 | 0.51 | – | – |
| History of smoking | −0.09 | 0.69 | – | – |
| Coronary artery disease | – | – | – | – |
Significant p values are highlighted in bold.
AVCd, aortic valve calcification density; BAV, bicuspid aortic valve; TAV, tricuspid aortic valve.