Risk of complications (HR) with 95% CI depending on warfarin treatment quality measured as TTR and INR variability divided into high/low using TTR 70% or the mean INR variability of 0.40 as cut-off
| End points studied | ΔSD−INR ≤0.40 INR | ΔSD−INR >0.40 INR |
|---|---|---|
| TTR ≥70% | ||
| Bleeding | 1 (ref) | 1.41 (1.07 to 1.84)* |
| Thrombosis | 1 (ref) | 1.31 (1.002 to 1.72)* |
| All-cause death | 1 (ref) | 1.68 (1.25 to 2.25)* |
| TTR <70% | ||
| Bleeding | 1.50 (1.01 to 2.38)* | 2.50 (1.99 to 3.15)* |
| Thrombosis | 0.84 (0.47 to 1.48) | 1.55 (1.21 to 1.99)* |
| All-cause death | 2.44 (1.58 to 3.78)* | 3.34 (2.62 to 4.27)* |
The best group with high TTR ≥70% and low variability ≤0.40 INR used as reference.
*p<0.05.
INR, international normalised ratio; TTR, time in therapeutic range.