Table 3

Rate of complications per 100 treatment years with 95% CI, according to MHV position, intended INR target, or warfarin treatment quality measured as TTR or INR variability, using TTR 70% or the mean INR variability of 0.40 as cut-off

BleedingsThrombosesDeath
Aortic valve prosthesis, N=3656
 Actual INR 2.2–2.72.74 (2.41 to 3.12)2.42 (2.10 to 2.77)1.79 (1.53 to 2.08)
 Actual INR 2.8–3.33.02 (2.35 to 3.81)2.28 (1.71 to 2.98)2.97 (2.36 to 3.69)
Mitral valve prosthesis, N=1031
 Actual INR 2.2–2.74.73 (3.72 to 5.94)2.95 (2.17 to 3.93)2.48 (1.80 to 3 to 33)
 Actual INR 2.8–3.33.97 (2.89 to 5.33)2.63 (1.77 to 3.77)4.17 (3.16 to 5.41)
Variability
 ≤0.40002.08 (1.78 to 2.41)1.90 (1.61 to 2.22)1.51 (1.26 to 1.79)
 ≥0.40014.33 (3.87 to 4.82)2.96 (2.59 to 3.38)3.31 (2.93 to 3.74)
TTR
 ≥70%2.30 (2.03 to 2.60)2.13 (1.86 to 2.41)1.68 (1.47 to 1.93)
 <70%5.13 (4.51 to 5.82)3.05 (2.58 to 3.59)4.00 (3.50 to 4.54)
  • INR, international normalised ratio; MHV, mechanical heart valve; TTR, time in therapeutic range.