Outcomes across study groups according to SYNTAX score terciles
| PCI (n=577) | CABG (n=589) | HR (95% CI) | p Value | |
|---|---|---|---|---|
| Overall | ||||
| Death/MI/stroke | 16.3% (94) | 11.5% (68) | 1.43 (1.05 to 1.96) | 0.023 |
| All-cause death | 10.1% (58) | 7.0% (41) | 1.47 (0.99 to 2.20) | 0.06 |
| Cardiac death | 6.6% (38) | 3.1% (18) | 2.18 (1.24 to 3.82) | 0.006 |
| Stroke | 1.9% (11) | 3.6% (21) | 0.54 (0.26 to 1.11) | 0.10 |
| MI | 7.6% (44) | 2.2% (13) | 3.53 (1.90 to 6.56) | <0.001 |
| Revascularisation | 16.5% (95) | 7.5% (44) | 2.41 (1.69 to 3.45) | <0.001 |
| MACCE | 27.4% (158) | 17.3% (102) | 1.71 (1.33 to 2.19) | <0.001 |
| SYNTAX score 0–22 (n=349, 29.9%) | n=173 | n=176 | ||
| Death/MI/stroke | 13.3% (23) | 10.8% (19) | 1.21 (0.66 to 2.23) | 0.54 |
| All-cause death | 5.8% (10) | 6.2% (11) | 0.90 (0.38 to 2.12) | 0.81 |
| Cardiac death | 3.5% (6) | 2.8% (5) | 1.19 (0.36 to 3.91) | 0.77 |
| Stroke | 1.2% (2) | 3.4% (6) | 0.33 (0.07 to 1.64) | 0.18 |
| MI | 6.9% (12) | 1.7% (3) | 4.04 (1.14 to 14.33) | 0.030 |
| Revascularisation | 16.2% (28) | 10.2% (18) | 1.59 (0.88 to 2.87) | 0.13 |
| MACCE | 24.9% (43) | 18.2% (32) | 1.37 (0.87 to 2.17) | 0.17 |
| SYNTAX score ≥23 (n=817, 70.1%) | n=404 | n=413 | ||
| Death/MI/stroke | 17.6% (71) | 11.9% (49) | 1.52 (1.06 to 2.19) | 0.025 |
| All-cause death | 11.9% (48) | 7.3% (30) | 1.70 (1.08 to 2.69) | 0.022 |
| Cardiac death | 7.9% (32) | 3.1% (13) | 2.57 (1.35 to 4.91) | 0.004 |
| Stroke | 2.2% (9) | 3.6% (15) | 0.63 (0.27 to 1.43) | 0.27 |
| MI | 7.9% (32) | 2.4% (10) | 3.34 (1.64 to 6.8) | 0.001 |
| Revascularisation | 16.6% (67) | 6.3% (26) | 2.98 (1.90 to 4.70) | <0.001 |
| MACCE | 28.5% (115) | 16.9% (70) | 1.86 (1.38 to 2.50) | <0.001 |
Intermediate (23–32) and high (≥33) SYNTAX scores terciles are pooled together in one group.
Cox regression models were stratified by trial.
CABG, coronary artery bypass graft surgery; MACCE, major adverse cardiovascular and cerebrovascular events (all-cause death, stroke, MI or all-cause revascularisation); MI, myocardial infarction; PCI, percutaneous coronary intervention.