Summary of studies on duration of DAPT
| No. of patients in each treatment group | Primary end point | Design and randomisation | Follow-up duration after randomisation (median) (months) | Results of the primary end point | |
|---|---|---|---|---|---|
| ARTIC-Interruption, 201495 | 12 months (n=624); 18–24 months (n=635) | Death, myocardial infarction, stent thrombosis, cerebrovascular accident or target vessel revascularisation | Superiority, randomisation at discontinuation of DAPT | 17 | Superiority of >12 months DAPT not shown |
| DAPT, 201496 | 12 months (n=4941); 36 months (n=5020) | Death, myocardial infarction, stent thrombosis, cerebrovascular accident or bleeding | Superiority, randomisation at discontinuation of DAPT | 18 | Superiority of 30-month DAPT shown |
| DES-LATE, 201397 | 12 months (n=2514) 36 months (n=2531) | Cardiac death, myocardial infarction or cerebrovascular accident | Superiority, randomisation at discontinuation of DAPT | 24 | Superiority of 24-month DAPT not shown |
| EXCELLENT, 201298 | 6 months (n=722) 12 months (n=721) | Cardiac death, myocardial infarction or cerebrovascular accident | Non-inferiority, randomisation at discontinuation of DAPT | 12 | Non-inferiority shown |
| ISAR-SAFE, 201489 | 6 months (n=1997) 12 months (n=2003) | Death, myocardial infarction, cerebrovascular accident, target vessel revascularisation or bleeding | Non-inferiority, randomisation at discontinuation of DAPT | 9 | Non-inferiority shown |
| ITALIC, 201490 | 6 months (n=1997) 12 months (n=941) | Death, myocardial infarction, stent thrombosis, cerebrovascular accident or bleeding | Non-inferiority, randomisation at the time of PCI | 12 | Non-inferiority shown |
| OPTIMIZE, 201391 | 3 months (n=1563); 12 months (n=1556) | Death, myocardial infarction, cerebrovascular accident or major bleeding | Non-inferiority, randomisation at the time of PCI | 12 | Non-inferiority shown |
| PRODIGY, 201299 | 6 months (n=751) 24 months (n=750) | Death, myocardial infarction or cerebrovascular accident | Superiority, randomisation 1 month after PCI | 24 | Superiority of 24-month DAPT not shown |
| RESET, 2012100 | 3 months (n=1059) 12 months (n=1058) | Cardiac death, myocardial infarction, stent thrombosis, target vessel revascularisation, or major bleeding | Non-inferiority, randomisation at the time of PCI | 12 | Non-inferiority shown |
| SECURITY, 2014101 | 6 months (n=682) 12 months (n=717) | Cardiac death, myocardial infarction, stent thrombosis, cerebrovascular accident, bleeding | Non-inferiority, randomisation at the time of PCI | 12 | Non-inferiority shown |
Reproduced with permission from Palmerini et al.75
DAPT, dual antiplatelet therapy; PCI, percutaneous coronary intervention.