HRs with 95% CIs for all-cause mortality, heart failure and myocardial infarction (MI) in relation to treatment for erectile dysfunction (ED), in 43 145 men with a first MI
| All-cause mortality | ||
| Subjects included in analysis* | No ED treatment (n=40 077) | ED treatment (n=3068) |
| Number of deaths (%) | 4741 (11.8) | 112 (3.7) |
| Incidence rate (cases/100 person-years) | 3.54 (3.44 to 3.64) | 1.43 (1.19 to1.72) |
| Unadjusted, HR (95% CI) | Referent | 0.44 (0.36 to 0.53) |
| Adjusted for age, HR (95% CI) | Referent | 0.60 (0.50 to 0.73) |
| Multivariable adjusted†, HR (95% CI) | Referent | 0.67 (0.55 to 0.81) |
| MI | ||
| Subjects included in analysis* | No ED treatment (n=40 198) | ED treatment (n=2947) |
| Number of MIs (%) | 3089 (7.7) | 99 (3.4) |
| Incidence rate (cases/100 person-years) | 2.43 (2.35 to 2.52) | 1.34 (1.10 to 1.64) |
| Unadjusted, HR (95% CI) | Referent | 0.83 (0.68 to 1.02) |
| Adjusted for age, HR (95% CI) | Referent | 0.91 (0.74 to 1.11) |
| Multivariable adjusted†, HR (95% CI) | Referent | 0.95 (0.77 to1.16) |
| Heart failure | ||
| Subjects included in analysis* | No ED treatment (n=40 144) | ED treatment (n=3001) |
| Number of events (%) | 2403 (6.0) | 41 (1.4) |
| Incidence rate (cases/100 person-years) | 1.86 (1.78 to 1.93) | 0.54 (0.40 to0.73) |
| Unadjusted, HR (95% CI) | Referent | 0.44 (0.32 to 0.60) |
| Adjusted for age, HR (95% CI) | Referent | 0.55 (0.40 to 0.75) |
| Multivariable adjusted†, HR (95% CI) | Referent | 0.60 (0.44 to 0.82) |
* Numbers do not sum up to group total since subjects can be included in the No ED treatment category initially and later change to the ED treatment category. †Adjusted for all variables in table 1, except for medication started the first 6 months following the event which was adjusted for as a time-dependent variable