Regression analysis evaluating TTNtv and alcohol excess as predictors of LVEF
| Unadjusted analysis | Adjusted analysis* | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variable | Estimate (change in LVEF,%) | 95% confidence intervals | P value | Estimate (change in LVEF,%) | 95% confidence intervals | P value | ||||
| Baseline: No TTNtv or alcohol excess | 0 | - | - | 0 | - | - | ||||
| TTNtv, no alcohol excess | 0.06 | −3.0 to 3.1 | 0.97 | −0.3 | −3.2 to 2.7 | 0.85 | ||||
| Alcohol excess, no TTNtv | −2.1 | −4.7 to 0.5 | 0.12 | −0.6 | −3.2 to 1.9 | 0.61 | ||||
| TTNtv and alcohol excess | −11.8 | −18.6 to −5.0 | <0.001 | −15.4 | −21.9 to −8.8 | <0.0001 | ||||
| TTNtv*Alcohol excess interaction§ | −9.7 | −17.5 to −1.9 | 0.02 | −14.4 | −21.9 to −7.0 | 0.0001 | ||||
Table shows unadjusted univariable and adjusted multivariable analyses of the effect of TTNtv and alcohol excess on baseline left ventricular ejection fraction.
*Adjusted for gender, a family history of DCM, a history of atrial fibrillation and the presence of mid wall fibrosis (late gadolinium enhancement on CMR) and NYHA class.
§ i.e. the effect of TTNtv and alcohol excess compared to either TTNtv alone or alcohol excess alone.