SPECT and PET tracers: established and in development
| Indication | SPECT | PET |
|---|---|---|
| Myocardial blood flow (currently available) | 201Thallium 99mTc-sestamibi 99mTc–tetrofosmin | 13N-NH3 (cyclotron) 15O-H2O (cyclotron) 82Rb |
| Myocardial blood flow (in development) | 123I-CMICE-013; 7′-(Z)-[123I] iodorotenone | 18F-flurpiridaz |
| Glucose metabolism | 18F-FDG (using 511 keV collimators) | 18F-FDG |
| Ventricular function | 99mTc–pertechnetate | |
| Sympathetic innervation | 123I-meta-iodo-benzyl-guanidine (123I-mIBG) | 11C-hydroxyephedrine 11C-epinephrine (cyclotron) |
| Amyloidosis | 99mTc–DPD | 18F-florbetapir |
| Hydroxyapatite (research) | 18F-NaF | |
| infection | 99mTc-labelled leucocytes | 18F-FDG; 68Ga |
| Inflammation (e.g., sarcoid) | 67Ga | 18F-FDG |
| Apoptosis | 99mTc-annexin V | 18F-annexin V; 68Ga-annexin V |
| Right to left shunt quantification | 99mTc-MAA | |
| Fatty acid | β-methyl-p-[123I]iodo-phenyl-pentadecanoic acid (123I-BMIPP) | 18F-FTHA |
| TCA cycle | 11C-acetate (cyclotron) | |
| Angiogenesis (integrin receptors) | 99mTc–RGD | 18F-fluciclatide; 18F-galacto-RGD |
| Macrophage activation | 18F-choline; 18F-folate; 18F-FDM; 11C-choline;11C-PK11195; 68Ga-DOTATATE | |
| Hypoxia | 18F-MISO | |
| MMP activation | 18F-RXP470 |
This is not a complete list which reflects the research activity, especially in PET tracers.
DPD, 3,3-diphosphono-1,2-propanodicarboxylic acid; FDG, fluorodeoxyglucose; MAA, macro-aggregated albumin; mIBG, metaiodobenzylguanidine; NaF, sodium fluoride; PET, positron emission tomography; SPECT, single photon emission computed tomography.