Genetic variants of transthyretin amyloidosis
| Genetic variant | Presenting age (mean) | Common ethnicity | Cardiac involvement | Other systemic involvement |
| Primary (AL) | 60–70 years | Any | 40%–50% | Kidney, liver, soft tissue, nerves, spleen |
| ATTR (wild type) | 70–80 years | Caucasian | Almost 100% | Carpal tunnel, spine, bladder |
| ATTR (Val122Ile) | ≥60 years | African/Caribbean | Almost 100% | Carpal tunnel, rarely nerves |
| ATTR (Thr60Ala) | ≥60 years | Caucasian (Irish) | 90% | Nerves common |
| ATTR (Val30Met) | 30–40 or 50–60 years | Any (Portuguese, Swedish, Japanese) | Uncommon in early onset, 40% of late onset | Nerves common |
AL, amylod light chain