Risk prediction metrics with for 7-KC in the cohort for incident CVD event
| Risk prediction models | C-statistic | NRI | IDI | |||
| C-statistic (95% CI) | p Value | Category-free NRI | p Value | IDI | p Value | |
| Model+IMT>1.0 mm | 0.808 (0.794 to 0.854) | – | – | – | ||
| Model+IMT>1.0 mm+7-KC | 0.836 (0.813 to 0.867) | 0.002 | 0.645 | <0.001 | 0.023 | <0.001 |
| Model+IMT+7-KC/total cholesterol | 0.842 (0.816 to 0.874) | <0.001 | 0.668 | <0.001 | 0.034 | <0.001 |
| Model+FH | 0.816 (0.798 to 0.863) | – | – | – | – | |
| Model+FH+7-KC | 0.841 (0.820 to 0.871) | 0.011 | 0.635 | 0.004 | 0.021 | 0.003 |
| Model+FH+7-KC/total cholesterol | 0.846 (0.823 to 0.878) | 0.006 | 0.652 | <0.001 | 0.025 | <0.001 |
| Model+hsCRP≥2 mg/L | 0.796 (0.778 to 0.825) | – | – | – | – | |
| Model+hsCRP≥2 mg/L+7-KC | 0.824 (0.802 to 0.854) | 0.008 | 0.610 | 0.015 | 0.017 | 0.009 |
| Model+hsCRP≥2 mg/L+7 KC/total cholesterol | 0.829 (0.807 to 0.863) | 0.003 | 0.631 | 0.008 | 0.026 | <0.001 |
7-KC and 7-KC/total cholesterol were categorised as high versus low levels using the above or below median. Model includes age, sex, BMI, current smoking, presence of hypertension, diabetes mellitus, LDL and HDL cholesterol, hsCRP, IMT, FH and statin use.
7-KC, 7-ketocholesterol; BMI, body mass index; CVD, cardiovascular disease; FH, family history of myocardial infarction; HDL, high-density lipoprotein; hsCRP, high-sensitivity C-reactive protein; IMT, carotid intima–media thickness; LDL, low-density lipoprotein.