Univariable Cox proportional hazards analysis for predicting cardiac death and composite endpoint
| Variables | Cardiac death | Composite endpoint | ||
| HR (95% CI) | p Value | HR (95% CI) | p Value | |
| Age (years) | 1.076 (1.052 to 1.100) | <0.001 | 1.035 (1.023 to 1.047) | <0.001 |
| NYHA functional class | 3.045 (1.924 to 4.819) | <0.001 | 1.621 (1.248 to 2.106) | <0.001 |
| Atrial fibrillation | 4.084 (2.130 to 7.828) | <0.001 | 1.966 (1.352 to 2.859) | <0.001 |
| Comorbidity index | 1.240 (1.004 to 1.530) | 0.046 | 1.218 (1.066 to 1.391) | 0.004 |
| LVDd (mm) | 0.931 (0.883 to 0.982) | 0.009 | 0.939 (0.908 to 0.970) | <0.001 |
| RA area (cm2) | 1.048 (1.022 to 1.075) | <0.001 | 1.029 (1.009 to 1.050) | 0.005 |
| Mitral valve area (cm2) | 0.142 (0.033 to 0.608) | 0.009 | 0.229 (0.097 to 0.538) | 0.001 |
| Peak gradient (mm Hg) | 1.075 (1.036 to 1.116) | <0.001 | 1.061 (1.036 to 1.086) | <0.001 |
| Echocardiographic score | 1.603 (1.354 to 1.897) | <0.001 | 1.399 (1.269 to 1.542) | <0.001 |
| SPAP (mm Hg) | 1.035 (1.023 to 1.048) | <0.001 | 1.020 (1.011 to 1.029) | <0.001 |
| RVFAC (%) | 0.962 (0.933 to 0.992) | 0.013 | 0.977 (0.958 to 0.995) | 0.015 |
| Moderate MR | 3.153 (1.571 to 6.329) | 0.001 | 1.717 (1.046 to 2.818) | 0.033 |
| Moderate or severe TR | 4.741 (2.538 to 8.858) | <0.001 | 1.853 (1.238 to 2.774) | 0.003 |
| Cn (mL/mm Hg) | 0.630 (0.463 to 0.858) | 0.003 | 0.780 (0.663 to 0.917) | 0.003 |
| TPG (mm Hg) | 1.050 (1.011 to 1.090) | 0.012 | 1.026 (1.000 to 1.053) | 0.046 |
| PVR (wood unit) | 1.163 (1.010 to 1.341) | 0.036 | 1.011 (0.903 to 1.132) | 0.847 |
| Postprocedural data | ||||
| Mitral valve area (cm2) | 0.042 (0.013 to 0.138) | <0.001 | 0.174 (0.087 to 0.348) | <0.001 |
| Moderate MR | 2.067 (1.043 to 4.096) | 0.038 | 2.539 (1.672 to 3.854) | <0.001 |
| Severe MR | 2.846 (0.678 to 11.948) | 0.153 | 7.602 (4.282 to 13.497) | <0.001 |
| Peak gradient (mm Hg) | 1.120 (1.067 to 1.175) | <0.001 | 1.130 (1.098 to 1.164) | <0.001 |
| Mean gradient (mm Hg) | 1.220 (1.113 to 1.338) | <0.001 | 1.328 (1.253 to 1.407) | <0.001 |
| LAV index (mL/m2) | 1.011 (1.003 to 1.019) | 0.009 | 1.009 (1.004 to 1.015) | 0.001 |
| SPAP (mm Hg) | 1.045 (1.032 to 1.059) | <0.001 | 1.036 (1.028 to 1.045) | <0.001 |
| RVFAC (%) | 0.941 (0.907 to 0.976) | 0.001 | 0.963 (0.941 to 0.985) | 0.001 |
| Moderate or severe TR | 5.500 (2.769 to 10.924) | <0.001 | 2.192 (1.454 to 3.303) | <0.001 |
| Mean PAP (mm Hg) | 1.055 (1.020 to 1.091) | 0.002 | 1.048 (1.028 to 1.069) | <0.001 |
| TPG (mm Hg) | 1.050 (1.003 to 1.098) | 0.037 | 1.027 (0.993 to 1.062) | 0.118 |
| PVR (wood unit) | 1.177 (0.970 to 1.429) | 0.099 | 1.097 (0.943 to 1.276) | 0.231 |
Cn, net atrioventricular compliance; LAV, left atrial volume; LVDd, left ventricular end-diastolic diameter; MR, mitral regurgitation; NYHA, New York Heart Association; PAP, pulmonary artery pressure; PVR, pulmonary vascular resistance; RA, right atrium; RVFAC, right ventricular fractional area change; SPAP, systolic pulmonary artery pressure; TPG, transpulmonary pressure gradient; TR, tricuspid regurgitation.