Description of baseline characteristics by persistence and severity of distress
| Never distressed | Sometimes distressed | Persistent mild distress | Persistent moderate-severe distress | p Value | |
| Subjects, n (%) | 587 (62) | 255 (27) | 73 (7.7) | 35 (3.7) | |
| GHQ score | 0.61±0.73 | 3.84±1.88 | 8.27±1.96 | 14.9 (3.44) | <0.001 |
| Pravastatin treatment, n (%) | 302 (51) | 118 (46) | 30 (41) | 17 (49) | 0.07 |
| Age (years) | 61.7±7.73 | 60.7±8.26 | 61±9.53 | 59.6±10.9 | 0.050 |
| Male, n (%) | 469 (80) | 207 (81) | 54 (74) | 32 (91) | 0.76 |
| Hypertension, n (%) | 220 (38) | 85 (33) | 34 (47) | 13 (37) | 0.98 |
| Diabetes, n (%) | 48 (8.2) | 24 (9.4) | 3 (4.1) | 3 (8.6) | 0.85 |
| Obese, n (%) | 107 (18.2) | 46 (18.0) | 23 (31.5) | 8 (22.9) | 0.11 |
| Total cholesterol (mmol/L) | 5.72±0.83 | 5.59±0.82 | 5.69±0.82 | 5.84±0.84 | 0.27 |
| HDL cholesterol (mmol/L) | 0.94±0.22 | 0.94±0.25 | 0.93±0.21 | 0.95±0.25 | 0.81 |
| Current smoker, n (%) | 45 (7.7) | 23 (9.0) | 7 (9.6) | 2 (5.7) | 0.59 |
| History MI, n (%) | 383 (65) | 158 (62) | 46 (63) | 21 (60) | 0.32 |
| History of stroke, n (%) | 13 (2.2) | 5 (2.0) | 7 (9.6) | 1 (2.9) | 0.053 |
| Angina grade >0, n (%) | 234 (40) | 114 (45) | 42 (58) | 20 (57) | 0.002 |
| Dyspnoea grade >0, n (%) | 306 (52) | 134 (53) | 51 (70) | 26 (74) | 0.013 |
| White blood count | 7.22±1.75 | 6.98±1.77 | 7.3±1.53 | 6.73±1.71 | 0.13 |
| C-reactive protein, mg/dL | 2.24 (1.12–4.34) | 2.46 (1.37–4.38) | 2.97 (1.32–5.48) | 3.65 (1.58–8.28) | 0.041 |
| BNP ≥50 pg/mL, n (%) | 128 (24.5) | 59 (25.5) | 16 (22.9) | 4 (12.5) | 0.59 |
| Troponin I ≥0.18 ng/mL, n (%) | 134 (25.8) | 57 (24.8) | 15 (21.7) | 6 (18.8) | 0.38 |
| Cystatin C ≥0.93 mg/L, n (%) | 132 (25.2) | 52 (22.6) | 19 (27.1) | 5 (15.6) | 0.44 |
Mean±SD, median (quartiles 1–3) or number (%) cut levels of BNP, D-Dimer and cystatin C are the upper quartile for the Long-Term Intervention with Pravastatin in Ischaemic Disease study population and for troponin I the upper tertile.25
BNP, B-type natriuretic peptide; HDL, high-density lipoprotein; MI, myocardial infarction.