Table 3

Multivariable adjusted HR and 95% CI for incident AF according to age of menopause categories, stratified by type of menopause

		Age of menopause (years)
Strata		<45	45–49	50–54	>54	p Trend	p Interaction
Natural menopause (n=21 739)	N	1557	5447	11 179	2942
	AF cases	74	224	455	135
	Model 1*	0.95 (0.72 to 1.27)	0.83 (0.67 to 1.03)	0.84 (0.70 to 1.02)	Reference	0.93
	Model 2†	0.96 (0.72 to 1.27)	0.83 (0.67 to 1.03)	0.84 (0.70 to 1.02)	Reference	0.97
	Model 3‡	0.94 (0.71 to 1.25)	0.82 (0.67 to 1.02)	0.83 (0.69 to 1.01)	Reference	0.88
	Model 4§	0.96 (0.72 to 1.27)	0.89 (0.72 to 1.10)	0.89 (0.74 to 1.08)	Reference	0.96
Surgical/chemotherapy- induced menopause (n=8295)	N	3592	2435	1657	351		0.45¶
	AF cases	181	137	89	25
	Model 1*	0.70 (0.46 to 1.06)	0.78 (0.51 to 1.20)	0.76 (0.49 to 1.19)	Reference	0.12
	Model 2†	0.70 (0.46 to 1.06)	0.79 (0.51 to 1.21)	0.76 (0.49 to 1.19)	Reference	0.12
	Model 3‡	0.69 (0.45 to 1.05)	0.78 (0.51 to 1.19)	0.76 (0.49 to 1.18)	Reference	0.11
	Model 4§	0.72 (0.47 to 1.09)	0.85 (0.55 to 1.30)	0.84 (0.54 to 1.31)	Reference	0.06

*Model 1: adjusted for body mass index, height, hypertension, diabetes, hypercholesterolaemia, race, smoking status, alcohol consumption, education, exercise, age at menarche and history of oral contraceptive use.
†Model 2: additionally adjusted for postmenopausal hormone therapy use.
‡Model 3: additionally adjusted for cardiovascular events occurring prior to AF onset.
§Model 4: additionally adjusted for age.
¶p for interaction for Model 4.
AF, atrial fibrillation.
Covariates were time updated as necessary. Data represent HRs and 95% CIs.