Table 2

Clinical outcomes of patients in the conservative management and initial AVR cohorts

Normal LVMI
N of patients with event/N of patients at risk (cumulative 5-year incidence (%))		High LVMI
N of patients with event/N of patients at risk (cumulative 5-year incidence (%))		UnadjustedAdjusted
HR
(95% CI)		p ValueHR
(95% CI)		p Valuep Value for interaction
A composite of aortic valve-related death or hospitalisation due to heart failureConservative management cohort164/691 (33)582/1480 (49)1.93
(1.63 to 2.31)		<0.0011.53
(1.26 to 1.85)		<0.0010.016
Initial AVR cohort26/217 (14)123/894 (16)1.12
(0.75 to 1.75)		0.590.96
(0.60 to 1.55)		0.88
All-cause deathConservative management cohort257/691 (42)684/1480 (52)1.36
(1.18 to 1.57)		<0.0011.11
(0.94 to 1.30)		0.230.39
Initial AVR cohort34/217 (19)176/894 (23)1.19
(0.84 to 1.75)		0.330.92
(0.61 to 1.39)		0.69
Aortic valve-related deathConservative management cohort86/691 (17)335/1480 (31)1.98
(1.57 to 2.53)		<0.0011.52
(1.18 to 1.96)		0.0010.42
Initial AVR cohort8/217 (5)51/894 (6)1.53
(0.77 to 3.48)		0.241.42
(0.65 to 3.08)		0.38
Heart failure hospitalisationConservative management cohort130/691 (28)471/1480 (43)1.98
(1.64 to 2.42)		<0.0011.64
(1.33 to 2.02)		<0.0010.0034
Initial AVR cohort18/217 (10)76/894 (12)0.99
(0.61 to 1.71)		0.980.89
(0.50 to 1.57)		0.68

  • Other abbreviations are same as in table 1.

  • AVR, aortic valve replacement; LVMI, left ventricular mass index.