Baseline characteristics of the outcome cohort by tertile of cMyC
| All patients (n=104) | Tertile 1 5–14 ng/L (n=35) | Tertile 2 15–26 ng/L (n=35) | Tertile 3 27–132 ng/L (n=34) | P value | |
| Age (years) | 68.2 (9.8) | 64.4 (10.5) | 70.1 (9.0) | 70.0 (9.1) | 0.02 |
| Sex (male), n (%) | 71 (68.3) | 21 (60.0) | 19 (54.3) | 31 (91.2) | 0.002 |
| BMI (kg/m2) | 27.9 (4.5) | 27.6 (4.1) | 28.1 (4.9) | 27.8 (4.7) | 0.91 |
| BSA (m2) | 1.9 (0.2) | 1.9 (0.2) | 1.9 (0.2) | 2.0 (0.2) | 0.19 |
| Comorbidity | |||||
| Diabetes mellitus, n (%) | 2 (1.9) | 1 (2.9) | 0 (0.0) | 1 (2.9) | 0.60 |
| Hypertension, n (%) | 57 (54.8) | 16 (45.7) | 24 (68.6) | 17 (50.0) | 0.13 |
| Hyperlipidaemia, n (%) | 7 (6.7) | 0 (0.0) | 5 (14.3) | 2 (5.9) | 0.06 |
| IHD, n (%) | 17 (16.3) | 2 (5.7) | 10 (28.6) | 5 (14.7) | 0.03 |
| Medications | |||||
| Aspirin, n (%) | 42 (40.4) | 13 (37.1) | 16 (45.7) | 13 (38.2) | 0.74 |
| Anticoagulant, n (%) | 10 (9.6) | 1 (2.9) | 4 (11.4) | 5 (14.7) | 0.23 |
| ACE-I/ARB, n (%) | 20 (19.2) | 5 (14.3) | 7 (20) | 8 (23.5) | 0.63 |
| Beta blocker, n (%) | 23 (22.1) | 8 (22.9) | 11 (31.4) | 4 (11.8) | 0.14 |
| Blood tests | |||||
| Creatinine (μmol/L) | 91.3 (21.3) | 85.3 (18.1) | 89.3 (17.9) | 100.1 (25.6) | 0.01 |
| eGFR (mL/min/1.73 m2) | 73.5 (17.4) | 77.2 (13.9) | 71.7 (16.4) | 71.6 (21.3) | 0.31 |
| Troponin I (ng/L) | 7.2 (5.4–12.6) | 4.9 (3.9–6.0) | 8.3 (6.7–10.6) | 14.3 (12.1–17.9) | <0.001 |
| Echo parameters | |||||
| AVmax (m/s) | 3.4 (0.7) | 3.4 (0.7) | 3.4 (0.8) | 3.5 (0.6) | 0.90 |
| AV area (cm2) | 1.0 (0.4) | 1.0 (0.4) | 1.0 (0.4) | 1.0 (0.4) | 0.89 |
| AV MPG (mm Hg) | 48.8 (19.2) | 47.6 (18.7) | 49.7 (21.8) | 49.2 (17.1) | 0.89 |
| Indexed LV mass (g/m2) | 184.4 (52.2) | 170.0 (56.8) | 175.7 (38.8) | 208.7 (52.0) | 0.004 |
| Ejection fraction (%) | 66 (31) | 69 (22) | 66 (25) | 61 (44) | 0.64 |
| CT coronary calcium score | 382.6 (611.1) | 370.3 (608.3) | 491.0 (783.2) | 283.6 (360.2) | 0.37 |
| Outcomes | |||||
| AVR, n (%) | 48 (46.2) | 19 (54.3) | 15 (42.9) | 14 (41.2) | 0.49 |
| Cardiac death, n (%) | 16 (15.4) | 4 (11.4) | 7 (20.0) | 5 (14.7) | 0.61 |
| All-cause death, n (%) | 36 (34.6) | 7 (20.0) | 14 (40.0) | 15 (44.1) | 0.08 |
Values are number (%), mean (SD) or median (IQR). Results in bold are statistically significant.
ACE-I, ACE inhibitor; ARB, angiotensin receptor blocker; AV, aortic valve; AVR, aortic valve replacement; BMI, body mass index; BSA, body surface area; cMyC, cardiac myosin-binding protein C; eGFR, estimated glomerular filtration rate; IHD, ischaemic heart disease; LV, left ventricle; MPG, mean pressure gradient.