Univariable odds ratios (ORs) of each baseline variable on 30-day mortality in the main analysis development cohort
| Variable* | OR (95% CI)† | P value |
| Mean-centred age | 1.01 (1.00 to 1.03) | 0.0751 |
| Female | 1.15 (0.92 to 1.44) | 0.2111 |
| Non-Caucasian | 0.75 (0.40 to 1.43) | 0.3840 |
| Diabetic | 0.86 (0.65 to 1.13) | 0.2712 |
| Current or ex-smoker | 1.00 (0.80 to 1.25) | 0.9893 |
| Mean-centred BMI | 0.97 (0.95 to 0.99) | 0.0051 |
| Glomerular filtration rate per 5 units increase | 0.95 (0.92 to 0.97) | <0.0001 |
| Renal failure | 1.70 (1.16 to 2.49) | 0.0062 |
| Recent MI | 1.65 (0.65 to 4.14) | 0.2899 |
| Pulmonary disease | 1.27 (1.00 to 1.61) | 0.0535 |
| Cerebrovascular disease | 0.92 (0.66 to 1.27) | 0.6155 |
| Extracardiac arteriopathy | 1.61 (1.26 to 2.05) | <0.0001 |
| Calcified aorta | 1.34 (1.02 to 1.76) | 0.0369 |
| Sinus rhythm | 0.76 (0.60 to 0.95) | 0.0163 |
| Previous cardiac surgery | 0.88 (0.69 to 1.13) | 0.3194 |
| Prior BAV | 1.46 (1.07 to 2.00) | 0.0181 |
| Previous PCI | 0.89 (0.67 to 1.18) | 0.4205 |
| Critical preoperative state | 2.94 (1.77 to 4.88) | <0.0001 |
| NYHA class IV | 1.49 (1.15 to 1.95) | 0.0030 |
| Poor mobility‡ | 2.74 (1.89 to 3.96) | <0.0001 |
| CSHA frail‡ | 1.91 (1.33 to 2.75) | <0.0001 |
| KATZ (per point drop from 6 points)‡ | 1.40 (1.24 to 1.58) | <0.0001 |
| PA systolic >60 mm Hg | 1.29 (0.96 to 1.75) | 0.0946 |
| Aortic peak gradient | 1.00 (0.99 to 1.00) | 0.0990 |
| Aortic valve area per 0.1 unit increase | 1.00 (0.95 to 1.04) | 0.8450 |
| LVEF<50% | 1.33 (1.06 to 1.66) | 0.0140 |
| More than one diseased vessel | 1.16 (0.93 to 1.46) | 0.1832 |
| Left main stem disease | 1.00 (0.58 to 1.74) | 0.9861 |
| Non-elective procedure | 1.77 (1.33 to 2.35) | <0.0001 |
| Non-transfemoral access | 2.12 (1.68 to 2.66) | <0.0001 |
*Variable definitions are given in online supplementary table 1.
†Each univariable OR was pooled across all 10 multiple imputed data sets.
‡The univariable ORs for the three frailty variables were estimated using only 2013–2014 data since this is the period in which these variables were recorded within the UK-TAVI Registry.
BAV, balloon aortic valvuloplasty; BMI, body mass index; CSHA, Canadian Study of Health and Aging; LVEF, left ventricular ejection fraction; MI, myocardial Infarction; NYHA, New York Heart Association Functional Classification; PA, pulmonary artery; PCI, percutaneous coronary intervention.