Baseline characteristics
| All participants | Non-anginal | Possible angina | |||
| Standard care | CT intervention | Standard care | CT intervention | ||
| n | 3770 | 735 | 712 | 1149 | 1174 |
| Age (years) | 56.62 (9.73) | 53.47 (9.68) | 54.37 (9.67) | 58.52 (9.24) | 58.10 (9.50) |
| Male | 2049 (54.4) | 405 (55.1) | 373 (52.4) | 619 (53.9) | 652 (55.5) |
| BMI (kg/m2) | 29.69 (5.97) | 29.45 (6.38) | 29.60 (6.28) | 29.88 (5.87) | 29.71 (5.60) |
| Hypertension | 1211 (32.1) | 172 (23.4) | 190 (26.7) | 412 (35.9) | 437 (37.2) |
| Hypercholesterolaemia | 2078 (55.1) | 275 (37.4) | 305 (42.8) | 742 (64.6) | 756 (64.4) |
| Diabetes mellitus | 370 (9.8) | 52 (7.1) | 63 (8.8) | 132 (11.5) | 123 (10.5) |
| Smoking habit | |||||
| Never smoked | 1816 (48.2) | 361 (49.1) | 350 (49.2) | 548 (47.7) | 557 (47.4) |
| Ex-smoker | 1182 (31.4) | 198 (26.9) | 203 (28.5) | 388 (33.8) | 393 (33.5) |
| Current smoker | 772 (20.5) | 176 (23.9) | 159 (22.3) | 213 (18.5) | 224 (19.1) |
| Atrial fibrillation | 76 (2.0) | 11 (1.5) | 13 (1.8) | 25 (2.2) | 27 (2.3) |
| Previous CVD | 123 (3.3) | 12 (1.6) | 25 (3.5) | 30 (2.6) | 56 (4.8) |
| Previous PVD | 42 (1.1) | 3 (0.4) | 12 (1.7) | 10 (0.9) | 17 (1.4) |
| Family history | 1558 (41.3) | 285 (38.8) | 295 (41.4) | 460 (40.0) | 518 (44.1) |
| Antiplatelet agent | 1662 (44.1) | 126 (17.1) | 133 (18.7) | 695 (60.5) | 708 (60.3) |
| Statin | 1459 (38.7) | 121 (16.5) | 132 (18.5) | 602 (52.4) | 604 (51.4) |
| Beta-blockade | 786 (20.8) | 46 (6.3) | 65 (9.1) | 330 (28.7) | 345 (29.4) |
| ACE inhibitor or ARB | 497 (13.2) | 69 (9.4) | 67 (9.4) | 171 (14.9) | 190 (16.2) |
| Chest pain symptoms | |||||
| Non-anginal | 1616 (42.9) | 735 (100.0) | 712 (100.0) | 86 (7.5) | 83 (7.1) |
| Atypical angina | 893 (23.7) | 0 (0.0) | 0 (0.0) | 436 (37.9) | 457 (38.9) |
| Typical angina | 1261 (33.4) | 0 (0.0) | 0 (0.0) | 627 (54.6) | 634 (54.0) |
| Abnormal resting ECG | 512 (13.6) | 0 (0.0) | 0 (0.0) | 265 (23.1) | 247 (21.0) |
| Exercise ECG | |||||
| Not performed/no result available | 758 (20.1) | 137 (18.6) | 128 (18.0) | 249 (21.7) | 244 (20.8) |
| Normal | 2047 (54.3) | 544 (74.0) | 529 (74.3) | 474 (41.3) | 500 (42.6) |
| Inconclusive | 505 (13.4) | 40 (5.4) | 47 (6.6) | 210 (18.3) | 208 (17.7) |
| Abnormal | 460 (12.2) | 14 (1.9) | 8 (1.1) | 216 (18.8) | 222 (18.9) |
| Baseline diagnosis of CHD | 1619 (42.9) | 69 (9.4) | 82 (11.5) | 723 (62.9) | 745 (63.5) |
| Baseline diagnosis of angina | 1246 (33.1) | 9 (1.2) | 8 (1.1) | 609 (53.0) | 620 (52.8) |
| Predicted 10-year CHD risk* | 17.08 (11.57) | 13.60 (10.11) | 14.99 (10.37) | 18.70 (12.35) | 18.93 (11.65) |
| Estimated PTP of CHD (NICE 2010) | |||||
| <10% | 412 (10.9) | 173 (23.5) | 163 (22.9) | 38 (3.3) | 38 (3.2) |
| 10%–29% | 717 (19.0) | 255 (34.7) | 258 (36.2) | 102 (8.9) | 102 (8.7) |
| 30%–59% | 997 (26.4) | 232 (31.6) | 214 (30.1) | 266 (23.2) | 285 (24.3) |
| 60%–89% | 942 (25.0) | 75 (10.2) | 77 (10.8) | 400 (34.8) | 390 (33.2) |
| >90% | 702 (18.6) | 0 (0.0) | 0 (0.0) | 343 (29.9) | 359 (30.6) |
*ASSIGN Score (see http://assign-score.com/).
Data are mean (SD) or value (%).
ARB, angiotensin receptor blocker; BMI, body mass index; CHD, coronary heart disease; CVD, cerebrovascular disease; NICE, National Institute of Health and Care Excellence; PTP, pretest probability; PVD, peripheral vascular disease.