Table 3

Baseline NYHA class and echocardiographic features in the studies included in the meta-analysis

Study	NYHA 3–4 (%)		MR grade 3–4 (%)		LVEF (%)		LVEDV, mL		LVEDD, mm
Study	FMR	DMR	FMR	DMR	FMR	DMR	FMR	DMR	FMR	DMR
ACCESS-EU	84	73	98	97	N/A	N/A	N/A	N/A	N/A	N/A
Braun et al. 2014¹⁴	98	81	83	96	35	58	193	139	64	56
Chan et al. 2012¹⁶	N/A	N/A	100	100	32	46	228	156	64	57
EVEREST II RCT	65	45	100	100	48	64	N/A	N/A	N/A	N/A
EVEREST II HRR	87	84	80	95	N/A	N/A	170	137	N/A	N/A
EVEREST II REALISM	86	84	78	91	42	60	162	124	58	51
GRASP	79	82	100	100	33	55	N/A	N/A	N/A	N/A
Pilot European sentinel registry	88	77	99	100	37	59	172	119	N/A	N/A
Rudolph et al. 2013¹⁹	96	95	100	100	37	57	222	148	68	60
Pooled population	87	77	89	95	39	58	178	131	61	54
p Value	<0.001		<0.001		<0.001		<0.001		<0.001

DMR, degenerative mitral regurgitation; EVEREST II, Endovascular Valve Edge-to-Edge Repair Study II; FMR, functional mitral regurgitation; LVEDD, left ventricular end-diastolic diameter; LVEDV, left ventricular end-diastolic volume; LVEF, left ventricular ejection fraction; MR, mitral regurgitation; NYHA, New York Heart Association; RCT, randomised controlled trial.