Summary of findings for the comparison of intensified patient care versus usual care
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | Participants (n) (studies) | Quality of the evidence (GRADE) | |
| Risk with usual care | Risk with intensified patient care | ||||
| Medication adherence at ≤6 months | Study population | OR 1.93 (1.29 to 2.88) | 11 204 (7 RCTs) | ⊕⊕⊕⊖† MODERATE | |
| 456 per 1000 | 618 per 1000 (519 to 707) | ||||
| Medication adherence at >6 months | Study population | OR 2.87 (1.91 to 4.29) | 663 (3 RCTs) | ⊕⊕⊕⊕ HIGH | |
| 705 per 1000 | 873 per 1000 (820 to 911) | ||||
| Reduction in LDL-C at ≤6 months (mg/dL) | Mean reduction in LDL-C at ≤6 months (mg/dL) was 0 | Mean reduction in LDL-C at ≤6 months (mg/dL) in the intervention group was 19.51 greater (8.51 greater to 30.51 greater) | – | 333 (3 RCTs) | ⊕⊕⊕⊖† MODERATE |
| Reduction in total serum cholesterol at ≤6 months (mg/dL) | Mean reduction in total serum cholesterol at ≤6 months (mg/dL) was 0 | Mean reduction in total serum cholesterol at ≤6 months (mg/dL) in the intervention group was 17.15 greater (1.17 greater to 33.14 greater) | – | 430 (4 RCTs) | ⊕⊕⊖⊖†‡ LOW |
| Reduction in total serum cholesterol at >6 mos (mg/dL) | Mean reduction in total serum cholesterol at >6 months (mg/dL) was 0 | Mean reduction in total serum cholesterol at >6 months (mg/dL) in the intervention group was 17.57 greater (14.95 greater to 20.19 greater) | – | 127 (2 RCTs) | ⊕⊕⊕⊕ HIGH |
GRADE, Grading of Recommendations, Assessment, Development and Evaluation Working Group grades of evidence: high quality: further research is very unlikely to change our confidence in the estimate of effect; moderate quality: further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate; low quality: further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate; very low quality: we are very uncertain about the estimate. RCT, Randomised Controlled Trial; LDL-C, Low Density Lipoprotein-Cholesterol.
*The risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
†Downgraded due to heterogeneity.
‡Downgraded due to wide CI.