Baseline characteristics
| Cohort (n=253) | Exposure to AT (n=182) | No exposure to AT (n=71) | p Value | |
| Age | ||||
| Mean (SD) | 31.4 (12.2 | 31.7 (11.0) | 31.2 (12.7) | |
| Median (IQR) | 29.5 (22.9–39.1) | 29.3 (22.6–39.1) | 29.8 (24.4–39.6) | 0.71 |
| Sex | ||||
| (% female) | 60.1 | 59.9 | 60.6 | 0.92 |
| Down syndrome (%) | 33.2 | 29.1 | 43.7 | 0.03 |
| WHO functional class (%) | ||||
| 1 | 4.9 | 2.2 | 11.6 | 0.002 |
| 2 | 31.1 | 28.7 | 37.7 | |
| 3 | 57.5 | 63.5 | 42.0 | |
| 4 | 6.5 | 5.6 | 8.7 | |
| Dominant lesion | ||||
| ASD | 10.7 | 11.6 | 8.5 | |
| VSD | 323.8 | 32.4 | 33.8 | |
| VSD | 19.0 | 17.6 | 22.5 | |
| PDA | 7.9 | 7.7 | 8.5 | |
| Multiple left to right shunts | 7.1 | 8.2 | 4.2 | |
| Aortopulmonary window | 0.8 | 1.1 | 0 | |
| Complex | 20.5 | 20.3 | 21.1 | |
| Other/unknown | 1.2 | 1.1 | 1.4 |
Data presented as means (SD) and medians (IQR) and percentages (%). Data available in 100% of subjects for each variable.
Age, age at study commencement; ASD, atrial septal defect; AT, advanced therapy; PDA, persistent ductus arteriosus; VSD, ventricular septal defect.