Baseline and procedural characteristics of the study population, according to anticoagulation therapy at hospital discharge
| Variable | Anticoagulation therapy | P value | |
| No, n=1759 | Yes, n=707 | ||
| Age (years) | 80.9±7.5 | 81.7±6.4 | 0.004 |
| Male sex | 809 (46.2) | 333 (47.5) | 0.561 |
| Body mass index (kg/m2) | 27.2±5.2 | 27.1±5.2 | 0.494 |
| Diabetes mellitus | 509 (29.9) | 205 (29.9) | 0.975 |
| Coronary artery disease | 924 (53.0) | 323 (46.0) | 0.002 |
| COPD | 458 (26.2) | 206 (29.4) | 0.119 |
| Atrial fibrillation | 191 (10.9) | 573 (80.9) | <0.001 |
| CKD (eGFR <60 mL/min) | 1199 (68.2) | 496 (70.2) | 0.362 |
| STS | 7.2±6.5 | 7.9±5.9 | 0.074 |
| Baseline echocardiogram | |||
| LVEF ≥50% | 1281 (72.8) | 483 (68.3) | 0.026 |
| Mean gradient (mm Hg) | 49.0±16.1 | 45.2±15.1 | <0.001 |
| Aortic regurgitation | |||
| None/trace | 1078 (67.1) | 406 (63.1) | 0.295 |
| Mild | 410 (25.5) | 188 (29.2) | |
| Moderate | 96 (5.9) | 41 (6.4) | |
| Severe | 23 (1.4) | 8 (1.2) | |
| Procedural | |||
| Approach | |||
| Transfemoral | 1390 (84.9) | 513 (77.9) | <0.001 |
| Transapical/transaortic | 248 (15.2) | 146 (22.2) | |
| Prothesis type | |||
| Balloon expandable | 797 (45.3) | 346 (48.9) | 0.108* |
| Cribier-Edwards | 56 (3.2) | 22 (3.1) | |
| SAPIEN | 250 (14.2) | 129 (18.3) | |
| SAPIEN XT | 422 (23.9) | 176 (24.9) | |
| SAPIEN 3 | 69 (3.9) | 19 (2.7) | |
| Self-expandable | 962 (54.7) | 361 (51.1) | |
| CoreValve | 801 (45.5) | 291 (41.2) | |
| Evolut R | 73 (4.2) | 40 (5.7) | |
| Portico | 20 (1.1) | 3 (0.4) | |
| DirectFlow | 51 (2.9) | 14 (1.9) | |
| Lotus | 15 (0.9) | 11 (1.6) | 0.269 |
| Other | 2 (0.1) | 2 (0.3) | |
| Discharge echocardiogram | |||
| LVEF ≥50% | 1369 (77.8) | 524 (74.1) | 0.051 |
| Mean gradient (mm Hg) | 9.8±4.6 | 9.4±4.5 | 0.032 |
| Aortic regurgitation | |||
| None/trace | 1386 (79.8) | 565 (81.2) | 0.597 |
| Mild | 320 (18.4) | 117 (16.8) | |
| Moderate | 30 (1.7) | 13 (1.9) | |
| Severe | 1 (0.1) | 1 (0.1) | |
| Discharge medication | |||
| Aspirin | 1543 (90.5) | 391 (56.0) | <0.001 |
| Clopidogrel | 1420 (83.2) | 226 (32.4) | <0.001 |
Categorical variables are reported as n (%) and continuous variables as mean±SD.
*Versus self-expandable.
CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; eGFR, estimated glomerular filtration rate; LVEF, left ventricular ejection fraction; STS, Society for Thoracic Surgeons risk score.