Baseline and procedural characteristics of the propensity-matched population, according to anticoagulation therapy at hospital discharge
| Variable | Anticoagulation therapy | P value | |
| No, n=622 | Yes, n=622 | ||
| Age (years) | 81.8±6.7 | 81.8±6.1 | 0.839 |
| Male sex | 293 (47.4) | 289 (46.9) | 0.864 |
| Body mass index (kg/m2) | 27.1±5.0 | 27.1±5.3 | 0.907 |
| Diabetes mellitus | 168 (27.9) | 187 (31.2) | 0.207 |
| Coronary artery disease | 287 (46.1) | 293 (47.1) | 0.776 |
| COPD | 193 (31.0) | 186 (29.9) | 0.712 |
| Atrial fibrillation | 65 (10.5) | 497 (79.9) | <0.001 |
| CKD (eGFR <60 mL/min) | 419 (67.4) | 432 (69.5) | 0.464 |
| STS | 7.8±6.6 | 7.7±5.7 | 0.846 |
| Baseline echocardiogram | |||
| LVEF ≥50% | |||
| Mean gradient (mm Hg) | 45.2±14.9 | 45.2±15.2 | 0.973 |
| Aortic regurgitation | |||
| None/trace | 375 (63.9) | 366 (63.4) | 0.752 |
| Mild | 166 (28.3) | 174 (30.2) | |
| Moderate | 40 (6.8) | 32 (5.6) | |
| Severe | 6 (1.0) | 5 (0.9) | |
| Procedural | |||
| Approach | |||
| Transfemoral | 497 (79.9) | 486 (78.1) | 0.486 |
| Transapical/transaortic | 125 (20.1) | 136 (21.9) | |
| Prothesis type | |||
| Balloon-expandable | 295 (47.4) | 320 (51.5) | 0.174* |
| Cribier-Edwards | 22 (3.5) | 22 (3.5) | |
| SAPIEN | 104 (16.7) | 117 (18.8) | |
| SAPIEN XT | 139 (22.4) | 165 (26.5) | |
| SAPIEN 3 | 30 (4.8) | 16 (2.6) | |
| Self-expandable | 327 (52.6) | 302 (48.6) | |
| CoreValve | 258 (41.5) | 242 (38.9) | |
| Evolut R | 36 (5.8) | 31 (5.0) | |
| Portico | 10 (1.6) | 3 (0.5) | |
| DirectFlow | 18 (2.9) | 13 (2.1) | |
| Lotus | 5 (0.8) | 11 (1.8) | |
| Other | 0 | 2 (0.3) | |
| Valve size | |||
| ≤23 mm | 171 (27.5) | 176 (28.3) | 0.800 |
| >23 mm | 451 (72.5) | 446 (71.7) | |
| Discharge echocardiogram | |||
| LVEF ≥50% | |||
| Mean gradient (mm Hg) | 9.8±4.3 | 9.4±4.5 | 0.095 |
| Aortic regurgitation | |||
| None/trace | 493 (80.3) | 496 (81.1) | 0.739 |
| Mild | 115 (18.7) | 107 (17.5) | |
| Moderate | 6 (0.9) | 8 (1.3) | |
| Severe | 0 | 1 (0.2) | |
| Discharge medication | |||
| Aspirin | 576 (92.6) | 359 (57.7) | <0.001 |
| Clopidogrel | 502 (80.7) | 202 (32.5) | <0.001 |
Categorical variables are reported as n (%); continuous variables are expressed as mean±SD.
*Versus self-expandable.
CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; LVEF, left ventricular ejection fraction.