Table 1

Relative effects of longer (>90 min) versus shorter (≤90 min) door-to-balloon delay on various clinical outcomes*

 OutcomesCohorts (n)Types of effect est.Effect estimates† (95% CI)I2 (%)Interaction P value‡
(a) Primary outcomes
 Short-term mortality
2 20 21 Adjusted OR1.54 (1.41 to 1.68)20.30.43
818 37–39 41 47 48 50 Crude OR1.33 (0.94 to 1.88)0.0
10Overall RE1.52 (1.40 to 1.65)16.2
 Medium-term to long-term mortality
2 20 34 Adjusted OR1.86 (1.47 to 2.34)0.00.22
618 25 44 47 48 50 Crude OR1.34 (0.89 to 2.01)57.9
146 Adjusted HR1.39 (1.00 to 1.94)
Overall RE1.53 (1.13 to 2.06)55.0
 Short-term mortality (per 30 min’ increase of D2BT)
317 22 33 Adjusted OR1.17 (1.05 to 1.30)96.9
(b) Other outcomes
 In-hospital shock
2 37 41 Crude OR4.51 (0.56 to 36.06)0.0
 12-month recurrent MI
518 34 42 47 Crude OR1.54 (1.18 to 2.01)0.00
 Short-term MACE
437 39 41 50 Crude OR1.22 (0.82 to 1.82)0.0
 Medium-term to long-term MACE
135 Adjusted HR1.02 (0.81 to 1.29)<0.00
418 34 44 50 Crude OR1.64 (1.54 to 1.74)0.0
5Overall RE1.47 (1.16 to 1.86)75.5
  • Forest plots of all pooled and accompanied sensitivity analyses and related funnel plots are provided in online supplementary appendix eFigures 7.1–7.11.

  • *Included only studies that defined D2B delay according to our stated definition in the Methods section and compared between D2B time <90 min and >90 min in a dichotomous fashion (primary analysis).

  • †Random-effects model, inverse variance method.

  • ‡Test for subgroup differences (random-effects model).

  • §Because the study by Brodie et al 47 involves a study cohort that is partially overlaps with the study by Brodie et a l,46 to avoid double counting, the study by Brodie et al 46 is excluded from the overall RE estimate.

  • MACE, major adverse cardiac event/composite endpoint; MI, myocardial Infarction; RE, relative effect.