Even rate and the association between use of ticagrelor as compared with clopidogrel and outcomes stratified by estimated glomerular filtration rate (eGFR)
| eGFR (mL/min/1.73 m2) | Events (n) and event rate (%/year) | Crude HR (95% CI) | Adjusted HR (95% CI) | P for interaction | |||||||||
| >60 | 30–60 | <30 | >60 | 30–60 | <30 | >60 | 30–60 | < 30 | |||||
| Ticagrelor, N=9538 | Clopidogrel, N=24 130 | Ticagrelor, N=1986 | Clopidogrel, N=7817 | Ticagrelor, N=210 | Clopidogrel, N=1525 | N=33 668 | N=9803 | N=1735 | N=33 668 | N=9803 | N=1735 | ||
| Primary outcome | |||||||||||||
| Death, MI or stroke | 441 (7.0) | 2482 (11.0) | 219 (18.0) | 1996 (33.0) | 55 (48.0) | 648 (64.0) | 0.54 (0.49 to 0.60) | 0.52 (0.45 to 0.60) | 0.72 (0.54 to 0.95) | 0.87 (0.76 to 0.99) | 0.82 (0.70 to 0.97) | 0.95 (0.69 to 1.29) | 0.55 |
| Secondary outcome | |||||||||||||
| Death | 212 (2.3) | 1120 (4.8) | 162 (8.7) | 1252 (18.0) | 55 (33.0) | 496 (41.0) | 0.46 (0.39 to 0.53) | 0.50 (0.42 to 0.59) | 0.81 (0.61 to 1.08) | 0.80 (0.66 to 0.97) | 0.83 (0.68 to 1.01) | 1.08 (0.79 to 1.49) | 0.04 |
| MI | 244 (3.8) | 1320 (5.9) | 85 (6.6) | 948 (14.0) | 15 (11.0) | 257 (20.0) | 0.58 (0.50 to 0.67) | 0.44 (0.35 to 0.55) | 0.53 (0.31 to 0.90) | 0.93 (0.77 to 1.12) | 0.76 (0.58 to 0.99) | 0.62 (0.35 to 1.12) | 0.39 |
| Stroke | 78 (1.2) | 431 (1.9) | 38 (2.9) | 273 (3.8) | 6 (4.4) | 73 (5.4) | 0.58 (0.45 to 0.74) | 0.70 (0.50 to 0.99) | 0.77 (0.33 to 1.81) | 0.81 (0.59 to 1.11) | 0.86 (0.57 to 1.31) | 1.38 (0.51 to 3.76) | 0.63 |
MI, myocardial infarction.