Table 4

Risk of adverse outcomes considering marital status in specific groups of participants

Outcome	Marital status and subgroups	Studies	No. of participants (not applicable, (NA) for studies with no crude result available)	Odds ratio (95% CI)	Overall effect, P value	Heterogeneity, I²%	Subgroup differences between men only and women only (P value, I²)
Mortality post stroke	Unmarried vs married
	All	3	29 419	1.08 (0.88 to 1.32)	0.47	43
	Women only	1	3156	0.95 (0.77 to 1.17)	0.62	–
	Men and women	2	26 263	1.24 (0.83 to 1.84)	0.29	24
Mortality post MI	Unmarried vs married
	All	11	>21456 (3 NA)	1.42 (1.14 to 1.76)	0.002	83
	Men only	2	>2453 (1 NA)	1.76 (1.24 to 2.49)	0.001	80	0.56, 0%
	Women only	2	>374 (1 NA)	1.38 (0.67 to 2.86)	0.38	61	0.56, 0%
	Men and women	9	>18629 (2 NA)	1.35 (1.00 to 1.83)	0.05	84
	Divorced vs married
	All	3	>4158 (1 NA)	1.36 (0.92 to 2.01)	0.13	85
	Men only	1	2525	1.91 (1.50 to 2.43)	<0.001	–	0.95, 0%
	Women only	1	447	1.87 (1.04 to 3.36)	0.04	–	0.95, 0%
	Men and women	2	>1186 (1 NA)	1.08 (0.95 to 1.22)	0.23	0
	Widowed vs married
	All	4	>9171 (1 NA)	1.68 (1.30 to 2.17)	<0.001	85
	Men only	1	2136	1.49 (0.77 to 2.89)	0.24	–	0.31, 2.3%
	Women only	1	368	2.74 (1.03 to 7.28)	0.04	–	0.31, 2.3%
	Men and women	3	>6667 (1 NA)	1.65 (1.24 to 2.20)	<0.001	92
MI post MI	Unmarried vs married
	All	2	1964	0.72 (0.14 to 3.60)	0.69	77
	Women only	1	222	0.29 (0.08 to 1.08)	0.07	–
	Men and women	1	1742	1.51 (0.68 to 3.37)	0.31	–
MACE post MI	Unmarried vs married
MACE post MI	Men and women	1	1742	1.31 (0.79 to 2.17)	0.29	–
Major bleeding post MI	Unmarried vs married
Major bleeding post MI	Men and women	1	1742	2.11 (0.55 to 8.10)	0.28	–
CVD post MI	Unmarried vs married
CVD post MI	Men and women	1	1813	1.07 (0.41 to 2.81)	0.89	–

CVD, cardiovascular disease; MACE, major adverse cardiac events; MI, myocardial infarction.