Adjusted baseline echocardiographic characteristics of patients with CTHF and NCTHF with available echocardiographic images
| Variables | NCTHF (n=834)* | CTHF (n=71)* | P values* |
| LVEF, % | 32 (31, 32) | 36 (33, 40) | 0.048 |
| LVEDVI, mL/m2 | 92.7±1.4 | 75.4±4.9 | <0.001 |
| LVESVI, mL/m2 | 63.6±1.3 | 48.5±4.7 | 0.002 |
| Mean wall thickness, cm | 0.98±0.01 | 0.94±0.03 | 0.16 |
| LV mass index, g/m2 | 117.3±1.3 | 96.7±4.8 | <0.001 |
| Relative wall thickness | 0.37±0.004 | 0.38±0.02 | 0.57 |
| E/A ratio | 1.59±0.04 | 1.90±0.15 | 0.042 |
| e′ septal, cm/s | 6.3±0.1 | 5.8±0.3 | 0.12 |
| E/e′ septal | 14.5±0.3 | 17.0±1.1 | 0.026 |
| EDP/LVEDVI ratio, mm Hg/mL/m2 | 0.26±0.004 | 0.33±0.01 | <0.001 |
| LAVI, mL/m2 | 37.7±0.6 | 30.2±2.2 | 0.001 |
| EDP/LAVI ratio, mm Hg/mL/m2 | 0.66±0.01 | 0.88±0.04 | <0.001 |
| Global longitudinal LV strain, % | −12.6±0.2 | −12.5±0.6 | 0.89 |
| Global circumferential LV strain, % | −18.9±0.3 | −19.6±0.8 | 0.41 |
Data are presented as mean±SE for all variables, except LVEF, which is presented as geometric mean (95% CI). The presented values of echocardiographic variables are adjusted for age and sex.
*Adjusted for age and sex.
CTHF, cancer therapy-induced heart failure; EDP, end-diastolic pressure; LAVI, left atrial volume index; LV, left ventricular; LVEDVI, left ventricular end-diastolic volume index; LVEF, left ventricular ejection fraction; LVESVI, left ventricular end-systolic volume index; NCTHF, non-cancer therapy-induced heart failure.