Table 3

Baseline cardiopulmonary exercise testing characteristics of the participants.

VariablesNCTHF (n=894)CTHF (n=75)P values*P values†
Peak VO2, mL/min/kg15.3±6.316.0±5.80.330.40
% Predicted peak VO2 61.2±20.262.4±20.20.620.44
VE/VCO2 slope33.0±8.832.4±6.90.550.43
  Resting HR, bpm72±1479±16<0.001<0.001
  Peak HR, bpm122±28138±31<0.0010.003
  Chronotropic index0.53±0.280.64±0.300.0010.024
  HR recovery at 1 min, bpm20±1522±170.250.11
  Resting SBP, mm Hg117±20112±190.0200.64
  Peak SBP, mm Hg141±29134±290.0490.29
  Resting DBP, mm Hg74±1171±130.0360.46
  Peak DBP, mm Hg75±1273±130.180.46
  Peak RER1.19±0.131.23±0.140.0060.048
  • Data are presented as mean±SD.

  • *Unadjusted.

  • †Adjusted for age, sex and body mass index.

  • CTHF, cancer therapy-induced heart failure; DBP, diastolic blood pressure; HR, heart rate; NCTHF, non-cancer therapy-induced heart failure; RER, respiratory exchange ratio; SBP, systolic blood pressure.