Relative risk (95% CI)P values
Unadjusted regression1.46 (1.17 to 1.83)0.001
Adjusted regression*2.10 (1.67 to 2.65)<0.001
Propensity score-matched regression†2.29 (1.81 to 2.90)<0.001
As above, adjusting for covariates with an SMD >0.102.24 (1.77 to 2.83)<0.001

  • *Adjusted for patient age and gender, type of combination product (ARB, ACE inhibitor or beta blocker), and total number of antihypertensive defined daily dosages (DDD) in the FC/FDC, number of other antihypertensive prescription items, number of other cardiovascular drugs, number of antiplatelet/anticoagulant drugs, number of cholesterol drugs, number of diabetes drugs and number of other prescribed items.

  • †Propensity score generated from logit model including all covariates adjusted for in *.

  • ARB, angiotensin II receptor blockers; FC, free combination; FDC, fixed-dose combination; SMD, standardised mean differences.