Table 3

Hazard ratios for the composite outcome of all-cause mortality, non-fatal myocardial infarction and late revascularisation according to the severity and extent of obstructive CAD (n=14 382)

	Unadjusted model			Risk factor-adjusted model
	HR	95% CI	P values	HR	95% CI	P values
CCTA models
Severity of obstructive CAD
No CAD	1.00			1.00
Non-obstructive CAD	3.13	2.32 to 4.23	<0.001	2.41	1.72 to 3.37	<0.001
Moderate-to-severe CAD	16.06	12.13 to 21.28	<0.001	10.22	7.35 to 14.21	<0.001
Any CTO	25.12	16.51 to 38.24	<0.001	14.54	9.11 to 23.20	<0.001
Any proximal CTO	30.75	19.58 to 48.31	<0.001	18.30	11.16 to 30.01	<0.001
Extent of obstructive CAD (no. of involved vessels with ≥50% stenosis)
No CAD	1.00			1.00
Non-obstructive CAD	3.13	2.32 to 4.23	<0.001	2.45	1.75 to 3.44	<0.001
One-vessel disease	13.14	9.72 to 17.75	<0.001	8.42	5.94 to 11.93	<0.001
Multivessel or left main disease	22.49	16.44 to 30.75	<0.001	14.82	10.27 to 21.40	<0.001
Any CTO	25.40	16.69 to 38.66	<0.001	15.31	9.59 to 24.45	<0.001
Any proximal CTO	31.11	19.80 to 48.87	<0.001	19.30	11.76 to 31.66	<0.001

Risk adjustment was performed based on differences in age, gender, cardiovascular risk factors and symptoms.
CAD, coronary artery disease; CCTA, coronary CT angiography; CTO, chronic total occlusion.