Relative risk (95% CI)P values
Unadjusted regression0.69 (0.66 to 0.73)<0.001
Adjusted regression*1.00 (0.94 to 1.05)0.934
Propensity score-matched regression† 1.09 (1.03 to 1.15)0.005
As above, adjusting for covariates with an SMD >0.101.07 (1.01 to 1.13)0.030

  • *Adjusted for patient age and gender, type of combination product (ARB, ACE inhibitor or beta blocker), and total number of antihypertensive defined daily dosages (DDD) in the FC/FDC, number of other antihypertensive prescription items, number of other cardiovascular drugs, number of antiplatelet/anticoagulant drugs, number of cholesterol drugs, number of diabetes drugs and number of other prescribed items.

  • ↵†Propensity score generated from logit model including all covariates adjusted for in *.

  • ARB, angiotensin II receptor blockers; FC, free combination; FDC, fixed-dose combination; SMD, standardised mean differences.