Relative risk (95% CI) | P values | |
Unadjusted regression | 0.69 (0.66 to 0.73) | <0.001 |
Adjusted regression* | 1.00 (0.94 to 1.05) | 0.934 |
Propensity score-matched regression† | 1.09 (1.03 to 1.15) | 0.005 |
As above, adjusting for covariates with an SMD >0.10 | 1.07 (1.01 to 1.13) | 0.030 |
*Adjusted for patient age and gender, type of combination product (ARB, ACE inhibitor or beta blocker), and total number of antihypertensive defined daily dosages (DDD) in the FC/FDC, number of other antihypertensive prescription items, number of other cardiovascular drugs, number of antiplatelet/anticoagulant drugs, number of cholesterol drugs, number of diabetes drugs and number of other prescribed items.
↵†Propensity score generated from logit model including all covariates adjusted for in *.
ARB, angiotensin II receptor blockers; FC, free combination; FDC, fixed-dose combination; SMD, standardised mean differences.