Intraoperative characteristics
| Thermic-1 | Thermic-2 | Overall | Total (n=200) | |||||
| Randomised to normothermic (n=28) | Randomised to hypothermic (n=31) | Randomised to normothermic (n=70) | Randomised to hypothermic (n=71) | Randomised to normothermic (n=98) | Randomised to hypothermic (n=102) | |||
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | ||
| Bypass data | ||||||||
| Duration of bypass (min) | Median (IQR) | 48.5 (39.0, 66.0) | 62.0 (47.0, 79.0) | 90.5 (66.0, 113.0) | 73.0 (57.0, 109.0) | 76.5 (51.0, 102.0) | 67.5 (54.0, 103.0) | 72.5 (52.0, 102.5) |
| Duration of cross-clamp (min)* | Median (IQR) | 22.0 (14.5, 33.0) | 32.0 (27.0, 49.0) | 60.5 (41.0, 82.0) | 44.0 (28.0, 84.0) | 51.0 (29.0, 71.0) | 39.0 (27.0, 63.0) | 44.0 (28.0, 68.0) |
| Haemodynamic instability prior to CPB | 4/69 (6%) | 4/71 (6%) | 4/69 (6%) | 4/71 (6%) | 8/140 (6%) | |||
| Need for cardioversion | 0/20 (0%) | 0/26 (0%) | 2/70 (3%) | 1/71 (1%) | 2/90 (2%) | 1/97 (1%) | 3/187 (2%) | |
| Ischaemic changes when coming off CPB | 1/59 (2%) | 1/54 (2%) | 1/59 (2%) | 1/54 (2%) | 2/113 (2%) | |||
| Cardioplegia | 67/70 (96%) | 66/71 (93%) | 67/70 (96%) | 66/71 (93%) | 133/141 (94%) | |||
| Lowest haematocrit† | Median (IQR) | 25.5 (23.5, 27.7) | 25.3 (23.3, 27.9) | 25.5 (23.5, 27.7) | 25.3 (23.3, 27.9) | 25.3 (23.5, 27.9) | ||
| Modified ultrafiltration | 5/22 (23%) | 6/22 (27%) | 18/70 (26%) | 22/71 (31%) | 23/92 (25%) | 28/93 (30%) | 51/185 (28%) | |
| If yes, mL‡ | Median (IQR) | 200.0 (200.0, 200.0) | 250.0 (200.0, 300.0) | 250.0 (230.0, 300.0) | 250.0 (200.0, 300.0) | 250.0 (225.0, 300.0) | 250.0 (220.0, 300.0) | |
| Temperatures | ||||||||
| Before CPB (°C)§ | Median (IQR) | 34.8 (34.0, 35.4) | 34.9 (33.9, 35.6) | 35.3 (34.6, 35.9) | 35.5 (34.5, 35.8) | 35.2 (34.5, 35.7) | 35.4 (34.4, 35.7) | 35.3 (34.5, 35.7) |
| During CPB (°C)¶ | Median (IQR) | 35.5 (34.9, 35.7) | 28.7 (28.0, 32.3) | 34.7 (34.2, 35.0) | 28.6 (28.0, 30.6) | 34.8 (34.3, 35.3) | 28.6 (28.0, 31.0) | 32.4 (28.4, 34.9) |
| Post-CPB (°C)** | Median (IQR) | 36.2 (36.0, 36.4) | 35.6 (34.8, 36.3) | 36.4 (36.0, 36.6) | 36.2 (35.9, 36.6) | 36.3 (36.0, 36.6) | 36.2 (35.8, 36.6) | 36.2 (35.9, 36.6) |
| Highest temperature (°C)†† | Median (IQR) | 36.4 (36.1, 36.9) | 36.2 (35.8, 36.7) | 36.9 (36.7, 37.2) | 36.9 (36.5, 37.1) | 36.9 (36.4, 37.1) | 36.7 (36.3, 37.1) | 36.8 (36.4, 37.1) |
| On cross-clamp removal (°C)‡‡ | Median (IQR) | 36.1 (35.8, 36.4) | 32.8 (28.8, 36.1) | 36.0 (35.7, 36.6) | 35.3 (32.7, 36.1) | 36.1 (35.7, 36.6) | 35.0 (31.7, 36.1) | 35.9 (34.6, 36.4) |
Further details are given in online supplementary table S3.
Missing data:
*Thermic-2 (4 normothermic, 5 hypothermic).
†Thermic-2 (4 normothermic, 2 hypothermic).
‡Thermic-1 (5 normothermic, 5 hypothermic), Thermic-2 (1 normothermic).
§Thermic-1 (5 normothermic, 3 hypothermic).
¶Thermic-1 (10 normothermic, 7 hypothermic).
**Thermic-1 (5 normothermic, 4 hypothermic), Thermic-2 (1 normothermic, 2 hypothermic).
††Thermic-1 (5 normothermic, 4 hypothermic).
‡‡Thermic-1 (17 normothermic, 13 hypothermic), Thermic-2 (18 normothermic, 18 hypothermic).
CPB, cardiopulmonary bypass.