Univariate and multivariable predictors of ventricular arrhythmia in hypertrophic cardiomyopathy
| UVA | OR | 95% CI | p-value | MVA | OR | 95% CI | p-value | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age | 1.04 | 1.01–1.08 | 0.02 | Age | 1.04 | 0.99–1.08 | 0.08 | |||||
| Sex | 0.95 | 0.35–2.60 | 0.92 | BOLD ΔSI ≤6.5% (lowest quartile) | 3.04 | 1.02–9.05 | 0.04 | |||||
| BMI | 1.06 | 0.96–1.16 | 0.26 | LGE mass | 1.06 | 1.01–1.12 | 0.04 | |||||
| Sarcomere+ | 0.54 | 0.22–1.37 | 0.20 | Max LVWT≥30 | 0.48 | 0.32–7.151 | 0.49 | |||||
| Max LVWT≥30 | 1.50 | 0.13–17.26 | 0.75 | Syncope | 2.08 | 0.27–15.87 | 0.86 | |||||
| LV mass | 1.01 | 0.99–1.01 | 0.26 | Family History of SCD | 0.27 | 0.06–1.22 | 0.11 | |||||
| LVEF | 0.96 | 0.90–1.02 | 0.19 | Abnormal BP response | 1.34 | 0.23–8.05 | 0.75 | |||||
| LGE mass | 1.07 | 1.02–1.13 | 0.005 | |||||||||
| MPRI | 0.43 | 0.12–1.55 | 0.43 | |||||||||
| LVOT obstruction | 0.78 | 0.20–3.06 | 0.72 | |||||||||
| Family history of SCD | 0.40 | 0.11–1.48 | 0.17 | |||||||||
| Syncope | 3.21 | 0.60–7.04 | 0.17 | |||||||||
| Abnormal BP response | 1.88 | 0.42–8.47 | 0.41 | |||||||||
| BOLD ΔSI ≤6.5% (lowest quartile) | 3.86 | 1.47–10.11 | 0.006 | |||||||||
Abnormal BP response Abnormal Blood Pressure response during exercise; BMI Body Mass Index; BOLD Blood Oxygen Level Dependent imaging; CI Confidence Interval; EF Ejection Fraction; LGE late gadolinium enhancement; LV left ventricular; LVOT Left Ventricular Outflow Obstruction≥30 mm Hg; LVWT left ventricular wall thickness; MPRI myocardial perfusion reserve index; MVA Multivariable; OR Odds Ratio; SCD sudden cardiac death; *Sarcomere+: presence of sarcomeric mutation; UVA univariate;