Table 2

Cardiac MRI data

nControlnHypothermiaMean difference (95% CI)P values
Primary outcome
 CMR, days after event mean (±SD)473.6 (±1.3)433.6 (±0.9)0.03 (−0.45 to 0.51)0.91
 MSI, intention-to-treat set (±SD)470.37 (±0.26)410.43 (±0.27)−0.06 (−0.17 to 0.05)0.27
 MSI; per-protocol set (±SD)470.37 (±0.26)340.46 (±0.26)−0.09 (−0.21 to 0.02)0.12
Subgroups
 MSI, anterior wall infarction (±SD)230.33 (±0.30)230.41 (±0.27)−0.08 (−0.25 to 0.09)0.36
 MSI, inferior wall infarction (±SD)240.41 (±0.21)180.46 (±0.27)−0.06 (−0.21 to 0.09)0.45
Secondary outcomes
 Ejection fraction day 4, mean % (±SD)4751 (±12)4251 (±12)−0.1 (−5.0 to 4.9)0.99
 End-diastolic volume day 4, mean mL (±SD)47137 (±48)42130 (±42)6.3 (−12.7 to 25.2)0.51
 Infarct size, mean mL (±SD)4729 (±23)4227 (±21)2.2 (−7.1 to 11.4)0.64
 Infarct size/LV myocardium, mean mL (±SD)4722 (±15)4222 (±14)0.9 (−5.3 to 7.0)0.79
 Myocardium at risk, mean mL (±SD)4745 (±26)4143 (±23)2.3 (−8.2 to 12.8)0.67
 Myocardium at risk/LV myocardium, mean % (±SD)4735 (±16)4135 (±16)−0.63 (−7.4 to 6.1)0.85
 Microvascular obstruction, mean mL (±SD)473.0 (±5.8)422.2 (±4.0)0.74 (−1.38 to 2.86)0.49
 Microvascular obstruction/infarct, mean % (±SD)476.7 (±8.7)426.4 (±11.0)0.38 (−3.77 to 4.53)0.86
Follow-up at day 195 (±15)
 CMR, days after event mean (±SD)44196 (±4)37195 (±6)0.7 (−1.3 to 2.8)0.49
 Ejection fraction day 195, % (±SD)4453 (±12)3554 (±9)−1.3 (−6.3 to 3.6)0.59
 End-diastolic volume day 195, mL (±SD)44137 (±42)35128 (±43)8.8 (−10.6 to 28.1)0.37
 Infarct size, mean mL (±SD)4116 (±13)3515 (±10)0.5 (−5.0 to 6.0)0.86
 Infarct size/LV myocardium day 195, % (±SD)4113 (±9)3514 (±9)−1.2 (−5.4 to 2.9)0.55
  • CMR, cardiac MRI; LV, left ventricular; MSI, myocardial salvage index.