Table 4

Diagnostic performance of the Manchester Acute Coronary Syndromes (MACS) and Troponin-only Manchester Acute Coronary Syndromes (T-MACS) models as ‘rule out’ strategies (ie, ‘very low risk’ vs all other risk groups; 95% CI in parentheses)

T-MACS, 0 hour onlyT-MACS, 0 hour + 3 hours
For ACSFor AMIFor ACSFor AMI
Sensitivity94.3 (88.0 to 97.9)95.5 (88.9 to 98.8)99.0 (94.4 to 100.0)100.0 (95.6 to 100.0)
Specificity49.1 (45.1 to 53.1)48.2 (44.2 to 52.2)36.7 (32.6 to 40.9)35.9 (31.9 to 40.0)
PPV24.2 (22.5 to 25.9)20.7 (19.3 to 22.2)22.0 (20.9 to 23.2)18.8 (17.9 to 19.8)
NPV98.0 (95.8 to 99.1)98.7 (96.7 to 99.5)99.5 (96.5 to 99.9)100.0 (NA)
LR+1.85 (1.69 to 2.03)1.84 (1.69 to 2.01)1.57 (1.46 to 1.68)1.56 (1.47 to 1.66)
LR-0.12 (0.05 to 0.25)0.09 (0.04 to 0.24)0.03 (0.00 to 0.20)0.00 (NA)
  • ACS, acute coronary syndromes; AMI, acute myocardial infarction; LR+, positive likelihood ratio; LR-, negative likelihood ration; NA, not available; NPV, negative predictive value; PPV, positive predictive value.