Table 3

Meta-regression model with the mean difference (%) in desphopho-uncarboxyated matrix Gla protein as the dependent variable

Variable	Coefficient	95% CI	P values	Tau²
	Unadjusted
No covariate				451.1
Year of publication	6.39	−1.24 to 14.02	0.10	232.7
Duration of follow-up	−0.82	−1.86 to 0.22	0.12	185.3
Vitamin K form	23.64	−13.33 to 60.60	0.21	278.0
Dose	−0.01	−0.04 to 0.02	0.42	366.1
	Adjusted
Model 1
Duration of follow-up	−0.82	−1.58 to 0.05	0.04	66.7
Vitamin K form	19.72	−6.97 to 46.42	0.15
Model 2
Duration of follow-up	−1.03	−1.45 to 0.61	<0.001	0.0
Dose	−0.02	−0.04 to 0.00	0.045
Model 3
Duration of follow-up	−0.51	−1.67 to 0.65	0.39	195.1
Year of publication	5.01	−2.99 to 13.00	0.22
Model 4
Duration of follow-up	−0.70	−2.23 to 0.83	0.37	339.5
Dose	−0.01	−0.06 to 0.04	0.68
Vitamin K form	6.74	−62.58 to 76.05	0.85
Model 5
Duration of follow-up	−0.81	−1.31 to 0.31	0.002	0.74
Dose	−0.02	−0.04 to 0.001	0.04
Year of publication	4.60	−0.93 to 10.13	0.10