Table 2

Summary statistics of indices of AS in patients without valvular outflow obstruction

Normal aortic valveAortic valve sclerosis
All studiesLVEF >35%MR ≤2Regular rhythmImage quality≥2All studiesLVEF >35%MR ≤2Regular rhythmImage quality≥2
Studies, n8190768577737735701264795756531950324997
AVA (cm2), mean±SD2.6±0.72.6±0.72.6±0.72.6±0.72.5±0.72.3±0.72.3±0.72.4±0.72.4±0.72.3±0.7
AVA ≤1.5 cm2, n (%)256 (3.1)219 (2.8)219 (2.8)216 (2.8)217 (3.1)600 (9.3)495 (8.6)425 (8.0)350 (7.0)504 (10.1)
 (95% CI)(2.7 to 3.5)(2.5 to 3.2)(2.4 to 3.2)(2.4 to 3.2)(2.7 to 3.5)(8.6 to 10.0)(7.9 to 9.3)(7.3 to 8.7)(6.3 to 7.7)(9.3 to 10.9)
AVA ≤1 cm2, n (%)38 (0.5)25 (0.3)31 (0.4)32 (0.4)32 (0.5)117 (1.8)87 (1.5)79 (1.5)52 (1.0)98 (2.0)
 (95% CI)(0.3 to 0.6)(0.2 to 0.5)(0.3 to 0.5)(0.3 to 0.6)(0.3 to 0.6)(1.5 to 2.1)(1.2 to 1.8)(1.2 to 1.8)(0.8 to 1.3)(1.6 to 2.3)
AVAi (cm2/m2), mean±SD1.4±0.41.4±0.41.4±0.41.4±0.41.4±0.41.3±0.41.3±0.41.3±0.41.4±0.41.3±0.4
AVAi ≤0.85 cm2/m2, n (%)332 (4.1)289 (3.8)287 (3.7)294 (3.8)285 (4.1)683 (10.6)545 (9.5)492 (9.2)410 (8.1)561 (11.2)
 (95% CI)(3.6 to 4.5)(3.3 to 4.2)(3.3 to 4.1)(3.4 to 4.2)(3.6 to 4.5)(9.9 to 11.4)(8.7 to 10.2)(8.5 to 10.0)(7.4 to 8.9)(10.4 to 12.1)
AVAi ≤0.60 cm2/m2, n (%)37 (0.5)32 (0.4)30 (0.4)32 (0.4)32 (0.5)145 (2.3)107 (1.9)102 (1.9)73 (1.5)119 (2.4)
 (95% CI)(0.3 to 0.6)(0.3 to 0.6)(0.2 to 0.5)(0.3 to 0.6)(0.3 to 0.6)(1.9 to 2.6)(1.5 to 2.2)(1.5 to 2.3)(1.1 to 1.8)(2.0 to 2.8)
Vratio, mean±SD0.8±0.10.8±0.10.8±0.10.8±0.10.8±0.10.7±0.20.7±0.20.7±0.20.7±0.20.7±0.2
Vratio ≤0.50, n (%)294 (3.6)229 (3.0)246 (3.2)252 (3.3)254 (3.6)939 (14.6)740 (12.9)672 (12.6)573 (11.4)768 (15.4)
 (95% CI)(3.2 to 4.0)(2.6 to 3.4)(2.8 to 3.6)(2.9 to 3.7)(3.2 to 4.1)(13.7 to 15.4)(12.0 to 13.7)(11.7 to 13.5)(10.5 to 12.3)(14.4 to 16.4)
Vratio ≤0.25, n (%)11 (0.1)3 (0.0)9 (0.1)8 (0.1)10 (0.1)8 (0.1)5 (0.1)3 (0.1)4 (0.1)6 (0.1)
 (95% CI)(0.1 to 0.2)(0.0 to 0.1)(0.0 to 0.2)(0.0 to 0.2)(0.1 to 0.2)(0.0 to 0.2)(0.0 to 0.2)(0.0 to 0.1)(0.0 to 0.2)(0.0 to 0.2)
  • Data presented as mean±SD, and number of patients and their proportion (% and 95% CI) showing values below the established cutoffs for moderate and severe AS.

  • AS, aortic valve stenosis; AVAi, indexed aortic valve area; LVEF, left ventricular ejection fraction;MR, Mitral Regurgitation; Vratio, velocity ratio.